Technology Process of (Z)-6-(2,3-dimethoxyphenyl)-3-methyl-2-hexenyl 2-diazoacetate
There total 9 articles about (Z)-6-(2,3-dimethoxyphenyl)-3-methyl-2-hexenyl 2-diazoacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(E)-2-(2-benzenesulfonylhydrazide)acetic acid chloride; (Z)-6-(2,3-dimethoxyphenyl)-3-methyl-2-hexen-1-ol;
With
N,N-dimethyl-aniline;
In
dichloromethane;
at 0 ℃;
for 0.25h;
With
triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 0.583333h;
DOI:10.1021/jo0351419
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 92 percent / aq. periodic acid / tetrahydrofuran / 2 h / 0 °C
2.1: 92 percent / NaBH4 / methanol / 2 h / 0 °C
3.1: 96 percent / triphenylphosphine; CBr4 / CH2Cl2 / 2 h / 0 °C
4.1: 96 percent / K2CO3 / methanol / 2 h / 20 °C
5.1: 100 percent / Et3N / CH2Cl2 / 0.33 h / 0 °C
6.1: n-BuLi / tetrahydrofuran; hexane / 3 h / 0 °C
6.2: tetrahydrofuran; hexane / 12 h / 20 °C
7.1: 2.10 g / TBAF / tetrahydrofuran / 1 h / 0 °C
8.1: N,N-dimethylaniline / CH2Cl2 / 0.25 h / 0 °C
8.2: 59 percent / Et3N / CH2Cl2 / 0.58 h / 0 - 20 °C
With
sodium tetrahydroborate; n-butyllithium; carbon tetrabromide; tetrabutyl ammonium fluoride; potassium carbonate; N,N-dimethyl-aniline; periodic acid; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jo0351419
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 100 percent / m-chloroperbenzoic acid / CH2Cl2 / 4 h / 20 °C
2.1: 92 percent / aq. periodic acid / tetrahydrofuran / 2 h / 0 °C
3.1: 92 percent / NaBH4 / methanol / 2 h / 0 °C
4.1: 96 percent / triphenylphosphine; CBr4 / CH2Cl2 / 2 h / 0 °C
5.1: 96 percent / K2CO3 / methanol / 2 h / 20 °C
6.1: 100 percent / Et3N / CH2Cl2 / 0.33 h / 0 °C
7.1: n-BuLi / tetrahydrofuran; hexane / 3 h / 0 °C
7.2: tetrahydrofuran; hexane / 12 h / 20 °C
8.1: 2.10 g / TBAF / tetrahydrofuran / 1 h / 0 °C
9.1: N,N-dimethylaniline / CH2Cl2 / 0.25 h / 0 °C
9.2: 59 percent / Et3N / CH2Cl2 / 0.58 h / 0 - 20 °C
With
sodium tetrahydroborate; n-butyllithium; carbon tetrabromide; tetrabutyl ammonium fluoride; potassium carbonate; N,N-dimethyl-aniline; periodic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jo0351419
