1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S,2R)-2-(piperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)thiourea

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Chemical Name:1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S,2R)-2-(piperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)thiourea
CAS No.:1262616-57-8
Molecular Formula:C₂₃H₂₃F₆N₃S
Molecular Weight:487.512
Hs Code.:

Synonyms:1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S,2R)-2-(piperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)thiourea

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Chemical Property of 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S,2R)-2-(piperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)thiourea

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Technology Process of 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S,2R)-2-(piperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)thiourea

There total 4 articles about 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S,2R)-2-(piperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1262616-56-7
(1S,2R)-2-(piperidin-1-yl)-2,3-dihydro-1H-inden-1-amine

: 23165-29-9
3,5-bistrifluoromethylphenylisothiocyanate

: 1262616-57-8
1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S,2R)-2-(piperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)thiourea

Guidance literature:: In dichloromethane; at 20 ℃;
DOI:10.1039/c0cc03489d

Reference yield:

: tert-butyl ((1S,2R)-2-amino-2,3-dihydro-1H-inden-1-yl)carbamate

: 1262616-57-8
1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S,2R)-2-(piperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)thiourea

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; potassium iodide / isopropyl alcohol / 48 h / 80 °C / sealed tube

2: hydrogenchloride / methanol / 5 h / 20 °C

3: dichloromethane / 0.5 h / 20 °C

With hydrogenchloride; potassium carbonate; potassium iodide; In methanol; dichloromethane; isopropyl alcohol;
DOI:10.1002/chem.201100927

Reference yield:

: 163061-74-3
(1S,2S)-1-amino-2,3-dihydro-1H-inden-2-ol

: 1262616-57-8
1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S,2R)-2-(piperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)thiourea

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / tetrahydrofuran; water / 3 h / 0 - 20 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

2.2: 20 °C

2.3: 8 h / 20 - 50 °C / Inert atmosphere

3.1: potassium carbonate; potassium iodide / isopropyl alcohol / 48 h / 80 °C / sealed tube

4.1: hydrogenchloride / methanol / 5 h / 20 °C

5.1: dichloromethane / 0.5 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; sodium carbonate; potassium carbonate; triphenylphosphine; potassium iodide; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol;
DOI:10.1002/chem.201100927