(3R,5S)-3,5-Dimethyl-1-({4-[2-({4-[(4-fluorophenyl)amino]piperidin-1-yl}carbonyl)pyridin-3-yl]phenyl}methyl)-4-tert-butoxycarbonyl-piperazine

Base Information

Chemical Name:(3R,5S)-3,5-Dimethyl-1-({4-[2-({4-[(4-fluorophenyl)amino]piperidin-1-yl}carbonyl)pyridin-3-yl]phenyl}methyl)-4-tert-butoxycarbonyl-piperazine
CAS No.:920511-03-1
Molecular Formula:C₃₅H₄₄FN₅O₃
Molecular Weight:601.764
Hs Code.:

Synonyms:(3R,5S)-3,5-Dimethyl-1-({4-[2-({4-[(4-fluorophenyl)amino]piperidin-1-yl}carbonyl)pyridin-3-yl]phenyl}methyl)-4-tert-butoxycarbonyl-piperazine

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Chemical Property of (3R,5S)-3,5-Dimethyl-1-({4-[2-({4-[(4-fluorophenyl)amino]piperidin-1-yl}carbonyl)pyridin-3-yl]phenyl}methyl)-4-tert-butoxycarbonyl-piperazine

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Technology Process of (3R,5S)-3,5-Dimethyl-1-({4-[2-({4-[(4-fluorophenyl)amino]piperidin-1-yl}carbonyl)pyridin-3-yl]phenyl}methyl)-4-tert-butoxycarbonyl-piperazine

There total 1 articles about (3R,5S)-3,5-Dimethyl-1-({4-[2-({4-[(4-fluorophenyl)amino]piperidin-1-yl}carbonyl)pyridin-3-yl]phenyl}methyl)-4-tert-butoxycarbonyl-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 920511-01-9
3-(4-{[(3R,5S)-3,5-dimethyl-4-tert-butoxycarbonyl-1-piperazinyl]methyl}phenyl)-2-pyridinecarboxylic acid

: 38043-08-2
4-(4-fluorophenylamino)-piperidine

: 920511-03-1
(3R,5S)-3,5-Dimethyl-1-({4-[2-({4-[(4-fluorophenyl)amino]piperidin-1-yl}carbonyl)pyridin-3-yl]phenyl}methyl)-4-tert-butoxycarbonyl-piperazine

Guidance literature:: 3-(4-{[(3R,5S)-3,5-dimethyl-4-tert-butoxycarbonyl-1-piperazinyl]methyl}phenyl)-2-pyridinecarboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 2h;

4-(4-fluorophenylamino)-piperidine; In N,N-dimethyl-formamide; at 25 ℃;

Reference yield:

: 920511-03-1
(3R,5S)-3,5-Dimethyl-1-({4-[2-({4-[(4-fluorophenyl)amino]piperidin-1-yl}carbonyl)pyridin-3-yl]phenyl}methyl)-4-tert-butoxycarbonyl-piperazine

: (3R,5S)-3,5-dimethyl-1-({4-[2-({4-[(4-fluorophenyl)amino]piperidin-1-yl}-carbonyl)pyridin-3-yl]phenyl}methyl)piperazine hydrochloride

Guidance literature:: (3R,5S)-3,5-Dimethyl-1-({4-[2-({4-[(4-fluorophenyl)amino]piperidin-1-yl}carbonyl)pyridin-3-yl]phenyl}methyl)-4-tert-butoxycarbonyl-piperazine; With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 1h;

With sodium hydrogencarbonate; In dichloromethane; water;

With hydrogenchloride; In diethyl ether; ethyl acetate; Product distribution / selectivity;