trifluoromethanesulfonic acid 2,5-bis-benzenesulfonyl-7-methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl ester

Base Information

Chemical Name:trifluoromethanesulfonic acid 2,5-bis-benzenesulfonyl-7-methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl ester
CAS No.:267666-42-2
Molecular Formula:C₂₅H₂₁F₃N₂O₈S₃
Molecular Weight:630.644
Hs Code.:

Synonyms:trifluoromethanesulfonic acid 2,5-bis-benzenesulfonyl-7-methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl ester

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Chemical Property of trifluoromethanesulfonic acid 2,5-bis-benzenesulfonyl-7-methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl ester

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Technology Process of trifluoromethanesulfonic acid 2,5-bis-benzenesulfonyl-7-methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl ester

There total 6 articles about trifluoromethanesulfonic acid 2,5-bis-benzenesulfonyl-7-methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 407-25-0
trifluoroacetic anhydride

: 196882-99-2
2,5-bis-benzenesulfonyl-8-hydroxy-7-methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

: 267666-42-2
trifluoromethanesulfonic acid 2,5-bis-benzenesulfonyl-7-methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl ester

Guidance literature:: With pyridine; In dichloromethane; at -78 - -45 ℃; for 2h;
DOI:10.1021/jo9916176

Reference yield:

: 34259-86-4
1-benzenesulfonyl-piperidin-4-one

: 267666-42-2
trifluoromethanesulfonic acid 2,5-bis-benzenesulfonyl-7-methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: p-TsOH*H₂O / 5 h

2: 71 percent / AlCl₃; Et₃N / diethyl ether / 72 h / 20 °C

3: 82 percent / TiCl₄; Ti(OiPr)4 / CH₂Cl₂ / -78 °C

4: 97 percent / pyridine / CH₂Cl₂ / 2 h / -78 - -45 °C

With pyridine; titanium(IV) isopropylate; aluminium trichloride; titanium tetrachloride; toluene-4-sulfonic acid; triethylamine; In diethyl ether; dichloromethane; 1: Addition / 2: Elimination / 3: Elimination / 4: Substitution;
DOI:10.1021/jo9916176

Reference yield:

: 41979-39-9
4-piperidone hydrochloride

: 267666-42-2
trifluoromethanesulfonic acid 2,5-bis-benzenesulfonyl-7-methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / K₂CO₃ / H₂O; CHCl₃ / 10 h / 20 °C

2: p-TsOH*H₂O / 5 h

3: 71 percent / AlCl₃; Et₃N / diethyl ether / 72 h / 20 °C

4: 82 percent / TiCl₄; Ti(OiPr)4 / CH₂Cl₂ / -78 °C

5: 97 percent / pyridine / CH₂Cl₂ / 2 h / -78 - -45 °C

With pyridine; titanium(IV) isopropylate; aluminium trichloride; titanium tetrachloride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In diethyl ether; dichloromethane; chloroform; water; 1: Substitution / 2: Addition / 3: Elimination / 4: Elimination / 5: Substitution;
DOI:10.1021/jo9916176