2,4,5-tribenzyloxyphenylpropionitrile

Base Information

• Chemical Name: 2,4,5-tribenzyloxyphenylpropionitrile
• CAS No.: 90304-35-1
• Molecular Formula: C₃₀H₂₇NO₃
• Molecular Weight: 449.549
• Mol file: 90304-35-1.mol

Synonyms:2,4,5-tribenzyloxyphenylpropionitrile

Chemical Property of 2,4,5-tribenzyloxyphenylpropionitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2,4,5-tribenzyloxyphenylpropionitrile

There total 3 articles about 2,4,5-tribenzyloxyphenylpropionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.1%

2,4,5-tribenzyloxyphenylacrylonitrile (90304-34-0) → 2,4,5-tribenzyloxyphenylpropionitrile (90304-35-1)

Guidance literature:

With sodium amalgam; In 1,4-dioxane; water; for 16h; Ambient temperature;

DOI:10.1007/BF00798427

Reference yield:

2,4,5-tribenzyloxybenzaldehyde (7298-35-3) → 2,4,5-tribenzyloxyphenylpropionitrile (90304-35-1)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine, AcONH₄ / toluene / 1 h / Heating

2: 9 g / pyridine, AcONH₄ / toluene; xylene / 144 h / Heating

3: 74.1 percent / 3percent Na/Hg / dioxane; H₂O / 16 h / Ambient temperature

With pyridine; sodium amalgam; ammonium acetate; In 1,4-dioxane; water; toluene; xylene;

DOI:10.1007/BF00798427

Reference yield:

2,4,5-tribenzyloxyphenyl-α-cyanoacrylic acid (90304-33-9) → 2,4,5-tribenzyloxyphenylpropionitrile (90304-35-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 9 g / pyridine, AcONH₄ / toluene; xylene / 144 h / Heating

2: 74.1 percent / 3percent Na/Hg / dioxane; H₂O / 16 h / Ambient temperature

With pyridine; sodium amalgam; ammonium acetate; In 1,4-dioxane; water; toluene; xylene;

DOI:10.1007/BF00798427

upstream raw materials:

2,4,5-tribenzyloxyphenylacrylonitrile

2,4,5-tribenzyloxybenzaldehyde

2,4,5-tribenzyloxyphenyl-α-cyanoacrylic acid

Downstream raw materials:

2,4,5-tribenzyloxyphenylpropylamine