N-phenyl-5-[2-(trifluoromethyl)phenyl]furan-2-carboxamide

Base Information

Chemical Name:N-phenyl-5-[2-(trifluoromethyl)phenyl]furan-2-carboxamide
CAS No.:622804-75-5
Molecular Formula:C₁₈H₁₂F₃NO₂
Molecular Weight:331.294
Hs Code.:
European Community (EC) Number:661-470-6
ChEMBL ID:CHEMBL1303147

Synonyms:N-phenyl-5-[2-(trifluoromethyl)phenyl]furan-2-carboxamide;KUC100030;622804-75-5;MLS000518251;MLS003172036;N-Phenyl-5-(2-(trifluoromethyl)phenyl)furan-2-carboxamide;SMR000129110;CHEMBL1303147;HMS2212I07;HMS3333O13;KUC100030N;AKOS002313871;KUC100030N-02;NCGC00243661-01;N-phenyl-5-[2-(trifluoromethyl)phenyl]-2-furamide;Z90332084

Suppliers and Price of N-phenyl-5-[2-(trifluoromethyl)phenyl]furan-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-phenyl-5-[2-(trifluoromethyl)phenyl]furan-2-carboxamide

Chemical Property:

XLogP3:4.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:331.08201311
Heavy Atom Count:24
Complexity:435

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)NC(=O)C2=CC=C(O2)C3=CC=CC=C3C(F)(F)F

Technology Process of N-phenyl-5-[2-(trifluoromethyl)phenyl]furan-2-carboxamide

There total 2 articles about N-phenyl-5-[2-(trifluoromethyl)phenyl]furan-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1929-89-1
furan-2-carboxylic acid phenylamide

: 392-83-6
o-trifluoromethylphenyl bromide

: 622804-75-5
5-(2-trifluoromethylphenyl)furan-2-carboxylic acid phenylamide

Guidance literature:: With Pd(C₃H₅)Cl(dppb); potassium acetate; In N,N-dimethyl acetamide; at 150 ℃; for 16h; regioselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201100312

Reference yield:

: 527-69-5
2-furancarbonyl chloride

: 62-53-3
aniline

: 622804-75-5
5-(2-trifluoromethylphenyl)furan-2-carboxylic acid phenylamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 20 °C

2: Pd(C₃H₅)Cl(dppb); potassium acetate / N,N-dimethyl acetamide / 16 h / 150 °C / Inert atmosphere

With Pd(C₃H₅)Cl(dppb); potassium acetate; triethylamine; In dichloromethane; N,N-dimethyl acetamide;
DOI:10.1002/ejoc.201100312