3-butyl-1-(3,5-dimethylphenyl)-5-methoxy-7-(methylsulfanyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dithione

Base Information

Chemical Name:3-butyl-1-(3,5-dimethylphenyl)-5-methoxy-7-(methylsulfanyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dithione
CAS No.:1636169-97-5
Molecular Formula:C₂₀H₂₄N₄OS₃
Molecular Weight:432.635
Hs Code.:

Synonyms:3-butyl-1-(3,5-dimethylphenyl)-5-methoxy-7-(methylsulfanyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dithione

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Chemical Property of 3-butyl-1-(3,5-dimethylphenyl)-5-methoxy-7-(methylsulfanyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dithione

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Technology Process of 3-butyl-1-(3,5-dimethylphenyl)-5-methoxy-7-(methylsulfanyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dithione

There total 3 articles about 3-butyl-1-(3,5-dimethylphenyl)-5-methoxy-7-(methylsulfanyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dithione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1636169-83-9
N-butyl-4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidine-5-carbothioamide

: 40046-30-8
3,5-dimethylphenyl isothiocyanate

: 1636169-97-5
3-butyl-1-(3,5-dimethylphenyl)-5-methoxy-7-(methylsulfanyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dithione

Guidance literature:: N-butyl-4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidine-5-carbothioamide; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 ℃;

3,5-dimethylphenyl isothiocyanate; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.25h;
DOI:10.3987/COM-14-13038

Reference yield:

: 89466-42-2
4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidine

: 1636169-97-5
3-butyl-1-(3,5-dimethylphenyl)-5-methoxy-7-(methylsulfanyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dithione

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

1.2: 0.08 h / -78 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil; N,N-dimethyl-formamide / 0 °C

2.2: 0.25 h / 0 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.3987/COM-14-13038

Reference yield:

: 6299-25-8
4,6-Dichloro-2-(methylthio)pyrimidine

: 1636169-97-5
3-butyl-1-(3,5-dimethylphenyl)-5-methoxy-7-(methylsulfanyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dithione

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

2.2: 0.08 h / -78 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil; N,N-dimethyl-formamide / 0 °C

3.2: 0.25 h / 0 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.3987/COM-14-13038