Technology Process of (7-azido-4-(prop-1-en-2-yl)hept-1-ynyl)benzene
There total 9 articles about (7-azido-4-(prop-1-en-2-yl)hept-1-ynyl)benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; triphenylphosphine;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 18h;
DOI:10.1002/anie.201007305
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 18 h / 50 °C / Inert atmosphere
2.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C
2.2: 19 h / -78 - 20 °C
3.1: hydrogenchloride / methanol; water / 1 h / 20 °C
4.1: di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; triphenylphosphine / tetrahydrofuran / 18 h / 0 - 20 °C
With
hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; sodium hexamethyldisilazane; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; water;
DOI:10.1002/anie.201007305
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 2 h / -78 °C
1.2: 20 h / -78 - -60 °C
2.1: diisobutylaluminium hydride / dichloromethane; toluene / 3 h / -78 °C
2.2: 1 h / -78 °C
3.1: tetrahydrofuran; toluene / 3 h / 70 °C
3.2: 20 °C
4.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 0 °C
5.1: pyridinium chlorochromate / dichloromethane / 3 h / 20 °C
6.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 18 h / 50 °C / Inert atmosphere
7.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C
7.2: 19 h / -78 - 20 °C
8.1: hydrogenchloride / methanol; water / 1 h / 20 °C
9.1: di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; triphenylphosphine / tetrahydrofuran / 18 h / 0 - 20 °C
With
1H-imidazole; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; sodium hexamethyldisilazane; diisobutylaluminium hydride; triethylamine; triphenylphosphine; pyridinium chlorochromate; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.201007305
