(+/-)-(Z)-N,N-dipropyl-4-(N-tert-bytoxycarbonyl-N-propenyl)amino-2-phenyl-2-hexenamide

Base Information

Chemical Name:(+/-)-(Z)-N,N-dipropyl-4-(N-tert-bytoxycarbonyl-N-propenyl)amino-2-phenyl-2-hexenamide
CAS No.:635292-26-1
Molecular Formula:C₂₆H₄₀N₂O₃
Molecular Weight:428.615
Hs Code.:

Synonyms:(+/-)-(Z)-N,N-dipropyl-4-(N-tert-bytoxycarbonyl-N-propenyl)amino-2-phenyl-2-hexenamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-(Z)-N,N-dipropyl-4-(N-tert-bytoxycarbonyl-N-propenyl)amino-2-phenyl-2-hexenamide

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Technology Process of (+/-)-(Z)-N,N-dipropyl-4-(N-tert-bytoxycarbonyl-N-propenyl)amino-2-phenyl-2-hexenamide

There total 7 articles about (+/-)-(Z)-N,N-dipropyl-4-(N-tert-bytoxycarbonyl-N-propenyl)amino-2-phenyl-2-hexenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 635292-25-0
(+/-)-(Z)-N,N-dipropyl-4-(N-allyl-N-tert-bytoxycarbonylamino)-2-phenyl-2-hexenamide

: 635292-26-1
(+/-)-(Z)-N,N-dipropyl-4-(N-tert-bytoxycarbonyl-N-propenyl)amino-2-phenyl-2-hexenamide

Guidance literature:: With hydridochlorotris(triphenylphosphine)ruthenium(II); In xylene; at 60 ℃;
DOI:10.1021/jm030226n

Reference yield:

: 152857-42-6
1-(2-hydroxymethyl)propylallylamine

: 635292-26-1
(+/-)-(Z)-N,N-dipropyl-4-(N-tert-bytoxycarbonyl-N-propenyl)amino-2-phenyl-2-hexenamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 13 percent / Et₃N / CH₂Cl₂ / 20 °C

2.1: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 3.5 h / -78 - 20 °C

3.1: LiCl; DBU / acetonitrile / 0.5 h / 20 °C

3.2: 24 mg / acetonitrile / 20 °C

4.1: 91 percent / aq. NaOH / ethanol / 70 °C

5.1: 52 percent / N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide; BOP; Et₃N / CH₂Cl₂ / 20 °C

6.1: 82 percent / RuHCl(CO)(PPh₃)3 / xylene / 60 °C

With sodium hydroxide; hydridochlorotris(triphenylphosphine)ruthenium(II); oxalyl dichloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; dimethyl sulfoxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium chloride; In ethanol; dichloromethane; acetonitrile; xylene; 2.1: Swern oxidation;
DOI:10.1021/jm030226n

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 635292-26-1
(+/-)-(Z)-N,N-dipropyl-4-(N-tert-bytoxycarbonyl-N-propenyl)amino-2-phenyl-2-hexenamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 13 percent / Et₃N / CH₂Cl₂ / 20 °C

2.1: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 3.5 h / -78 - 20 °C

3.1: LiCl; DBU / acetonitrile / 0.5 h / 20 °C

3.2: 24 mg / acetonitrile / 20 °C

4.1: 91 percent / aq. NaOH / ethanol / 70 °C

5.1: 52 percent / N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide; BOP; Et₃N / CH₂Cl₂ / 20 °C

6.1: 82 percent / RuHCl(CO)(PPh₃)3 / xylene / 60 °C

With sodium hydroxide; hydridochlorotris(triphenylphosphine)ruthenium(II); oxalyl dichloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; dimethyl sulfoxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium chloride; In ethanol; dichloromethane; acetonitrile; xylene; 2.1: Swern oxidation;
DOI:10.1021/jm030226n