5'-(methyloxy)-4'-{[3-(4-morpholinyl)propyl]oxy}acetophenone

Base Information

• Chemical Name: 5'-(methyloxy)-4'-{[3-(4-morpholinyl)propyl]oxy}acetophenone
• CAS No.: 1004735-86-7
• Molecular Formula: C₁₆H₂₃NO₄
• Molecular Weight: 293.363
• Mol file: 1004735-86-7.mol

Synonyms:5'-(methyloxy)-4'-{[3-(4-morpholinyl)propyl]oxy}acetophenone

Chemical Property of 5'-(methyloxy)-4'-{[3-(4-morpholinyl)propyl]oxy}acetophenone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5'-(methyloxy)-4'-{[3-(4-morpholinyl)propyl]oxy}acetophenone

There total 1 articles about 5'-(methyloxy)-4'-{[3-(4-morpholinyl)propyl]oxy}acetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

morpholine (110-91-8,99108-56-2) + 1-(3-methoxy-4-hydroxyphenyl)ethanone (498-02-2) + 1,3,2-dioxathiane 2,2-dioxide (1073-05-8) → 5'-(methyloxy)-4'-{[3-(4-morpholinyl)propyl]oxy}acetophenone (1004735-86-7)

Guidance literature:

1-(3-methoxy-4-hydroxyphenyl)ethanone; With lithium hydroxide; In tetrahydrofuran; water; for 0.5h; Reflux;

1,3,2-dioxathiane 2,2-dioxide; In tetrahydrofuran; water; for 3h; Heating;

morpholine; In tetrahydrofuran; water; Reflux;

Reference yield: 70.0%

5'-(methyloxy)-4'-{[3-(4-morpholinyl)propyl]oxy}acetophenone (1004735-86-7) → 1-[5-methoxy-4-(3-morpholin-4-yl-propoxy)-2-nitro-phenyl]-ethanone (1219937-96-8)

Guidance literature:

5'-(methyloxy)-4'-{[3-(4-morpholinyl)propyl]oxy}acetophenone; With nitric acid; trifluoroacetic acid; In dichloromethane; at 10 - 20 ℃;

With sodium hydroxide; In dichloromethane; water; at 25 - 30 ℃; pH=11;

upstream raw materials:

morpholine

1-(3-methoxy-4-hydroxyphenyl)ethanone

1,3,2-dioxathiane 2,2-dioxide

Downstream raw materials:

1-[5-methoxy-4-(3-morpholin-4-yl-propoxy)-2-nitro-phenyl]-ethanone