Chlorozinc(1+);1-methanidyl-3-methoxybenzene

Base Information

• Chemical Name: Chlorozinc(1+);1-methanidyl-3-methoxybenzene
• CAS No.: 312693-16-6
• Molecular Formula: C₈H₉ClOZn
• Molecular Weight: 222.002
• DSSTox Substance ID: DTXSID80392990
• Mol file: 312693-16-6.mol

Synonyms:chlorozinc(1+);1-methanidyl-3-methoxybenzene;312693-16-6;3-methoxybenzylzinc chloride;DTXSID80392990

Chemical Property of Chlorozinc(1+);1-methanidyl-3-methoxybenzene

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 9.23000
• Density: g/cm³
• LogP: 2.69790
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 219.963334
• Heavy Atom Count: 11
• Complexity: 82.6

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Methoxybenzylzinc chloride solution 0.5 M in THF ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,Xn
• Statements: 14-19-22-36/38-40-36/37
• Safety Statements: 16-26-33-36-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=CC(=C1)[CH2-].Cl[Zn+]

Technology Process of Chlorozinc(1+);1-methanidyl-3-methoxybenzene

There total 1 articles about Chlorozinc(1+);1-methanidyl-3-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromomethyl-3-methoxybenzene (874-98-6) + zinc(II) chloride (7646-85-7,24359-56-6) → (3-methoxybenzyl)zinc(II) chloride (312693-16-6)

Guidance literature:

1-bromomethyl-3-methoxybenzene; With magnesium; In tetrahydrofuran; at 0 ℃;

zinc(II) chloride; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.202109290

Reference yield: 80.0%

C18H24F2 + (3-methoxybenzyl)zinc(II) chloride (312693-16-6) → C26H33FO

Guidance literature:

With [RhCl((S,S)-Fc-tfb(*))]2; zinc(II) chloride; In tetrahydrofuran; at 25 ℃; for 14h; enantioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.202109290

Reference yield: 75.0%

C13H22F2 + (3-methoxybenzyl)zinc(II) chloride (312693-16-6) → C21H31FO

Guidance literature:

With [RhCl((S,S)-Fc-tfb(*))]2; zinc(II) chloride; In tetrahydrofuran; at 25 ℃; for 14h; Reagent/catalyst; Temperature; enantioselective reaction; Catalytic behavior; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.202109290

upstream raw materials:

1-bromomethyl-3-methoxybenzene

zinc(II) chloride

Downstream raw materials:

{(S)-6-[(R)-7-fluoro-4-(3-methoxy-benzyl)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

Refernces