N-[5-cyano-2-(4-morpholinyl)-1,3-thiazol-4-yl]-N-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}acetamide

Base Information

• Chemical Name: N-[5-cyano-2-(4-morpholinyl)-1,3-thiazol-4-yl]-N-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}acetamide
• CAS No.: 1256290-36-4
• Molecular Formula: C₁₉H₁₉F₃N₄O₂S
• Molecular Weight: 424.447

Synonyms:N-[5-cyano-2-(4-morpholinyl)-1,3-thiazol-4-yl]-N-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}acetamide

Chemical Property of N-[5-cyano-2-(4-morpholinyl)-1,3-thiazol-4-yl]-N-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}acetamide

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Technology Process of N-[5-cyano-2-(4-morpholinyl)-1,3-thiazol-4-yl]-N-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}acetamide

There total 2 articles about N-[5-cyano-2-(4-morpholinyl)-1,3-thiazol-4-yl]-N-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(bromomethyl)-2-methyl-3-(trifluoromethyl)benzene (261952-16-3) + N-[5-cyano-2-(4-morpholinyl)-1,3-thiazol-4-yl]acetamide (1256290-35-3) → N-[5-cyano-2-(4-morpholinyl)-1,3-thiazol-4-yl]-N-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}acetamide (1256290-36-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 3h;

Reference yield:

4-amino-2-(4-morpholinyl)-1,3-thiazole-5-carbonitrile (1069114-63-1) → N-[5-cyano-2-(4-morpholinyl)-1,3-thiazol-4-yl]-N-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}acetamide (1256290-36-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine; dmap / 80 °C

1.2: 0.25 h

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C

With pyridine; dmap; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/ml300045b

Reference yield: 32.0%

N-[5-cyano-2-(4-morpholinyl)-1,3-thiazol-4-yl]-N-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}acetamide (1256290-36-4) → 5-methyl-4-(2-methyl-3-(trifluoromethyl)benzyl)-2-morpholino[1,3]thiazolo[4,5-d]pyrimidin-7(4H)-one (1256289-67-4)

Guidance literature:

With sodium peroxoborate tetrahydrate; potassium carbonate; In methanol; at 55 ℃;

DOI:10.1021/ml300045b

upstream raw materials:

1-(bromomethyl)-2-methyl-3-(trifluoromethyl)benzene

N-[5-cyano-2-(4-morpholinyl)-1,3-thiazol-4-yl]acetamide

4-amino-2-(4-morpholinyl)-1,3-thiazole-5-carbonitrile

Downstream raw materials:

5-methyl-4-(2-methyl-3-(trifluoromethyl)benzyl)-2-morpholino[1,3]thiazolo[4,5-d]pyrimidin-7(4H)-one

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