N-(2-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-2,5-di(bithiophen-2-yl)thiophene-3-carboxamide

Base Information

• Chemical Name: N-(2-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-2,5-di(bithiophen-2-yl)thiophene-3-carboxamide
• CAS No.: 1050503-38-2
• Molecular Formula: C₂₉H₁₈F₃NO₂S₅
• Molecular Weight: 629.793

Synonyms:N-(2-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-2,5-di(bithiophen-2-yl)thiophene-3-carboxamide

Chemical Property of N-(2-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-2,5-di(bithiophen-2-yl)thiophene-3-carboxamide

Chemical Property:

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Technology Process of N-(2-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-2,5-di(bithiophen-2-yl)thiophene-3-carboxamide

There total 1 articles about N-(2-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-2,5-di(bithiophen-2-yl)thiophene-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2,5-dibromo-N-(2-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)thiophene-3-carboxamide (1050503-39-3) + 2,2'-bithiophene-5-boronic acid (132898-95-4) → N-(2-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-2,5-di(bithiophen-2-yl)thiophene-3-carboxamide (1050503-38-2)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 5h; Heating;

DOI:10.1021/jo801178y

Reference yield: 52.0%

N-(2-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-2,5-di(bithiophen-2-yl)thiophene-3-carboxamide (1050503-38-2) → N-(2-(2,2,2-trifluoroacetyl)phenyl)-2,5-di(bithiophen-2-yl)thiophene-3-carboxamide (1050503-36-0)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jo801178y

upstream raw materials:

2,5-dibromo-N-(2-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)thiophene-3-carboxamide

2,2'-bithiophene-5-boronic acid

Downstream raw materials:

N-(2-(2,2,2-trifluoroacetyl)phenyl)-2,5-di(bithiophen-2-yl)thiophene-3-carboxamide

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