1-hydroxy-2-trityloxymethyl-1,2,3a,8a-tetrahydro-8-oxa-3-selena-3b,7-diazacyclopenta[a]inden-6-one

Base Information

• Chemical Name: 1-hydroxy-2-trityloxymethyl-1,2,3a,8a-tetrahydro-8-oxa-3-selena-3b,7-diazacyclopenta[a]inden-6-one
• CAS No.: 1146697-60-0
• Molecular Formula: C₂₈H₂₄N₂O₄Se
• Molecular Weight: 531.47
• Mol file: 1146697-60-0.mol

Synonyms:1-hydroxy-2-trityloxymethyl-1,2,3a,8a-tetrahydro-8-oxa-3-selena-3b,7-diazacyclopenta[a]inden-6-one

Chemical Property of 1-hydroxy-2-trityloxymethyl-1,2,3a,8a-tetrahydro-8-oxa-3-selena-3b,7-diazacyclopenta[a]inden-6-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-hydroxy-2-trityloxymethyl-1,2,3a,8a-tetrahydro-8-oxa-3-selena-3b,7-diazacyclopenta[a]inden-6-one

There total 17 articles about 1-hydroxy-2-trityloxymethyl-1,2,3a,8a-tetrahydro-8-oxa-3-selena-3b,7-diazacyclopenta[a]inden-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-(3,4-dihydroxy-5-trityloxymethyl-tetrahydro-selenophen-2-yl)-1H-pyrimidine-2,4-dione (1146697-59-7) → 1-hydroxy-2-trityloxymethyl-1,2,3a,8a-tetrahydro-8-oxa-3-selena-3b,7-diazacyclopenta[a]inden-6-one (1146697-60-0)

Guidance literature:

With TCI; In toluene; at 100 ℃; for 15h;

DOI:10.1007/s12272-014-0466-6

Reference yield: 69.0%

1-(2,2’-anhydro-4-seleno-β-D-ribofuranosyl)uracil (1620879-55-1) + trityl chloride (76-83-5) → 1-hydroxy-2-trityloxymethyl-1,2,3a,8a-tetrahydro-8-oxa-3-selena-3b,7-diazacyclopenta[a]inden-6-one (1146697-60-0)

Guidance literature:

With pyridine; dmap; at 20 - 55 ℃; for 15h;

DOI:10.1016/j.ejmech.2014.06.031

Reference yield: 23.0%

1-[3-hydroxy-4-(tetrahydro-pyran-2-yloxy)-5-trityloxymethyl-tetrahydroselenophen-2-yl]-1H-pyrimidine-2,4-dione (1187425-02-0) → 1-hydroxy-2-trityloxymethyl-1,2,3a,8a-tetrahydro-8-oxa-3-selena-3b,7-diazacyclopenta[a]inden-6-one (1146697-60-0) + 1-[3-fluoro-4-(tetrahydro-pyran-2-yloxy)-5-trityloxymethyl-tetrahydroselenophen-2-yl]-1H-pyrimidine-2,4-dione (1187425-03-1)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at -78 - 0 ℃;

DOI:10.1021/jm900852b

upstream raw materials:

1-[3-hydroxy-4-(tetrahydro-pyran-2-yloxy)-5-trityloxymethyl-tetrahydroselenophen-2-yl]-1H-pyrimidine-2,4-dione

1-(3,4-dihydroxy-5-trityloxymethyl-tetrahydro-selenophen-2-yl)-1H-pyrimidine-2,4-dione

1-[2,2’-anhydro-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-seleno-β-D-ribofuranosyl]uracil

1-(2,2’-anhydro-4-seleno-β-D-ribofuranosyl)uracil

Downstream raw materials:

1-(tetrahydro-pyran-2-yloxy)-2-trityloxymethyl-1,2,3a,8a-tetrahydro-8-oxa-3-selena-3b,7-diazacyclopenta[a]inden-6-one

1-[3-hydroxy-4-(tetrahydro-pyran-2-yloxy)-5-trityloxymethyl-tetrahydroselenophen-2-yl]-1H-pyrimidine-2,4-dione

1-[3-fluoro-4-(tetrahydro-pyran-2-yloxy)-5-trityloxymethyl-tetrahydroselenophen-2-yl]-1H-pyrimidine-2,4-dione