N,N-dimethyl-4-[3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]aniline

Base Information

Chemical Name:N,N-dimethyl-4-[3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]aniline
CAS No.:1280291-11-3
Molecular Formula:C₂₁H₁₇F₃N₄
Molecular Weight:382.388
Hs Code.:

Synonyms:N,N-dimethyl-4-[3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]aniline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N-dimethyl-4-[3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]aniline

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Technology Process of N,N-dimethyl-4-[3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]aniline

There total 5 articles about N,N-dimethyl-4-[3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443283-95-1
N,N-dimethyl-4-[3-phenyl-4-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazolo[3,4-b]pyridin-6-yl]aniline

: 1280291-11-3
N,N-dimethyl-4-[3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]aniline

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere; Reflux;

Reference yield:

: 1443283-93-9
6-bromo-3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine

: 1280291-11-3
N,N-dimethyl-4-[3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]aniline

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tripotassium phosphate dihydrate / water; 1,2-dimethoxyethane / 0.25 h / 150 °C / Inert atmosphere; Microwave irradiation

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tripotassium phosphate dihydrate; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;

Reference yield:

: 827-41-8
3-phenylpyrazol-5-amine

: 1280291-11-3
N,N-dimethyl-4-[3-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]aniline

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; water / 18 h / 90 °C

2: phosphorus(V) oxybromide / toluene / 18 h / 90 °C

3: triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tripotassium phosphate dihydrate / water; 1,2-dimethoxyethane / 0.25 h / 150 °C / Inert atmosphere; Microwave irradiation

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tripotassium phosphate dihydrate; tetrabutyl ammonium fluoride; water; acetic acid; triethylamine; phosphorus(V) oxybromide; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene; 4: |Suzuki Coupling;