2-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}isonicotinic acid

Base Information

Chemical Name:2-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}isonicotinic acid
CAS No.:632622-76-5
Molecular Formula:C₂₄H₁₈ClFN₂O₃
Molecular Weight:436.87
Hs Code.:

Synonyms:2-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}isonicotinic acid

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Chemical Property of 2-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}isonicotinic acid

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Technology Process of 2-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}isonicotinic acid

There total 7 articles about 2-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}isonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 2-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}isonicotinic acid ethyl ester

: 632622-76-5
2-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}isonicotinic acid

Guidance literature:: With sodium hydroxide; water; In ethanol; for 1.5h; Heating / reflux;

Reference yield:

: 632625-64-0
5-chloro-2-((4-methoxybenzyl)oxy)benzaldehyde

: 632622-76-5
2-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}isonicotinic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / ethanol / 18 h / Heating / reflux

2: toluene / 12 h / 150 °C

3: sodium hydroxide; water / ethanol / 1.5 h / Heating / reflux

4: hydrogenchloride / 1,4-dioxane / 0.25 h / 20 °C

5: potassium carbonate / DMF (N,N-dimethyl-formamide) / 16 h / 60 °C

6: sodium hydroxide; water / ethanol / 1.5 h / Heating / reflux

With hydrogenchloride; sodium hydroxide; water; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; potassium carbonate; triethylamine; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); ethanol; toluene;

Reference yield:

: 2-{2-[5-chloro-2-(4-methoxybenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}isonicotinic acid

: 632622-76-5
2-{2-[5-chloro-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}isonicotinic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 0.25 h / 20 °C

2: potassium carbonate / DMF (N,N-dimethyl-formamide) / 16 h / 60 °C

3: sodium hydroxide; water / ethanol / 1.5 h / Heating / reflux

With hydrogenchloride; sodium hydroxide; water; potassium carbonate; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); ethanol;