(2S,3S,4R)-5-(tert-butyldiphenylsilyloxy)-2,3-epoxy-4-methylpentan-1-ol

Base Information

Chemical Name:(2S,3S,4R)-5-(tert-butyldiphenylsilyloxy)-2,3-epoxy-4-methylpentan-1-ol
CAS No.:214060-14-7
Molecular Formula:C₂₂H₃₀O₃Si
Molecular Weight:370.564
Hs Code.:

Synonyms:(2S,3S,4R)-5-(tert-butyldiphenylsilyloxy)-2,3-epoxy-4-methylpentan-1-ol

Suppliers and Price of (2S,3S,4R)-5-(tert-butyldiphenylsilyloxy)-2,3-epoxy-4-methylpentan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S,4R)-5-(tert-butyldiphenylsilyloxy)-2,3-epoxy-4-methylpentan-1-ol

Chemical Property:

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Technology Process of (2S,3S,4R)-5-(tert-butyldiphenylsilyloxy)-2,3-epoxy-4-methylpentan-1-ol

There total 5 articles about (2S,3S,4R)-5-(tert-butyldiphenylsilyloxy)-2,3-epoxy-4-methylpentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 127665-68-3
(4S)-5-(tert-butyldiphenylsilyloxy)-4-methyl-2-penten-1-ol

: 214060-14-7
(2S,3S,4R)-5-(tert-butyldiphenylsilyloxy)-2,3-epoxy-4-methylpentan-1-ol

Guidance literature:: With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate; In dichloromethane;
DOI:10.1248/cpb.46.1335

Reference yield:

: 91751-24-5,92817-88-4,123284-89-9,112897-04-8
(R)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropanal

: 214060-14-7
(2S,3S,4R)-5-(tert-butyldiphenylsilyloxy)-2,3-epoxy-4-methylpentan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / benzene / 17 h / Ambient temperature

2: 91 percent / diisobutylaluminum hydride / CH₂Cl₂; hexane / 1.5 h / -78 - -60 °C

3: 98 percent / titanium tetraisopropoxide, diethyl L-(+)-tartrate, 4 Angstroem molecular sieves, tert-butylhydroperoxide / CH₂Cl₂; 2,2,4-trimethyl-pentane / 23 h / -25 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate; 4 A molecular sieve; diisobutylaluminium hydride; In 2,2,4-trimethylpentane; hexane; dichloromethane; benzene;
DOI:10.1248/cpb.47.308

Reference yield:

: 95514-04-8,129029-85-2,120346-83-0
(S)-3-(tert-butyldiphenylsilyloxy)-2-methylpropan-1-ol

: 214060-14-7
(2S,3S,4R)-5-(tert-butyldiphenylsilyloxy)-2,3-epoxy-4-methylpentan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / DMSO, (COCl)2, Et₃N / CH₂Cl₂ / 2 h / -78 - -55 °C

2: 98 percent / benzene / 17 h / Ambient temperature

3: 91 percent / diisobutylaluminum hydride / CH₂Cl₂; hexane / 1.5 h / -78 - -60 °C

4: 98 percent / titanium tetraisopropoxide, diethyl L-(+)-tartrate, 4 Angstroem molecular sieves, tert-butylhydroperoxide / CH₂Cl₂; 2,2,4-trimethyl-pentane / 23 h / -25 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; oxalyl dichloride; diethyl (2R,3R)-tartrate; 4 A molecular sieve; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In 2,2,4-trimethylpentane; hexane; dichloromethane; benzene;
DOI:10.1248/cpb.47.308