(2S,3S,4R)-4-[[(cyanoimino)phenoxymethyl]amino]-6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran

Base Information

Chemical Name:(2S,3S,4R)-4-[[(cyanoimino)phenoxymethyl]amino]-6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran
CAS No.:335382-50-8
Molecular Formula:C₂₁H₂₂N₄O₇
Molecular Weight:442.428
Hs Code.:

Synonyms:(2S,3S,4R)-4-[[(cyanoimino)phenoxymethyl]amino]-6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S,4R)-4-[[(cyanoimino)phenoxymethyl]amino]-6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran

Chemical Property:

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Technology Process of (2S,3S,4R)-4-[[(cyanoimino)phenoxymethyl]amino]-6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran

There total 8 articles about (2S,3S,4R)-4-[[(cyanoimino)phenoxymethyl]amino]-6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 79463-77-7
N-cyanodiphenylcarbonimidate

: 380912-59-4
(2S,3S,4R)-4-amino-3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-6-nitro-2H-1-benzopyran

: 335382-50-8
(2S,3S,4R)-4-[[(cyanoimino)phenoxymethyl]amino]-6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran

Guidance literature:: With triethylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 12h;

Reference yield:

: (2S,3S,4R)-6-nitro-2-methyl-2-dimethoxymethyl-2H-benzopyran

: 79463-77-7
N-cyanodiphenylcarbonimidate

: 335382-50-8
(2S,3S,4R)-4-[[(cyanoimino)phenoxymethyl]amino]-6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide;

Reference yield:

: 335382-02-0
(2S)-2-methyl-2-dimethoxymethyl-6-nitro-2H-1-benzopyran

: 335382-50-8
(2S,3S,4R)-4-[[(cyanoimino)phenoxymethyl]amino]-6-nitro-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran

Guidance literature:: Multi-step reaction with 3 steps

1: (S,S)-Mn(III)-salen complex; NaOCl; Na₂HPO₄ / CH₂Cl₂ / 0 - 20 °C

2: aq. NH₃ / ethanol / 50 °C

3: 64 percent / Et₃N / dimethylformamide; propan-2-ol / 20 °C

With ammonium hydroxide; sodium hypochlorite; disodium hydrogenphosphate; (S,S)-Mn(III)-salen; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm010183f