(1S,3S,4R,7S,9R)-3,7-diisopropyl-4-(4-methoxy-phenyl)-6-oxo-5-oxa-10-azabicyclo[7.1.0]decane-10-sulfonic acid 2,2,2-trichloro-ethyl ester

Base Information

Chemical Name:(1S,3S,4R,7S,9R)-3,7-diisopropyl-4-(4-methoxy-phenyl)-6-oxo-5-oxa-10-azabicyclo[7.1.0]decane-10-sulfonic acid 2,2,2-trichloro-ethyl ester
CAS No.:1200341-39-4
Molecular Formula:C₂₃H₃₂Cl₃NO₆S
Molecular Weight:556.935
Hs Code.:

Synonyms:(1S,3S,4R,7S,9R)-3,7-diisopropyl-4-(4-methoxy-phenyl)-6-oxo-5-oxa-10-azabicyclo[7.1.0]decane-10-sulfonic acid 2,2,2-trichloro-ethyl ester

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Chemical Property of (1S,3S,4R,7S,9R)-3,7-diisopropyl-4-(4-methoxy-phenyl)-6-oxo-5-oxa-10-azabicyclo[7.1.0]decane-10-sulfonic acid 2,2,2-trichloro-ethyl ester

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Technology Process of (1S,3S,4R,7S,9R)-3,7-diisopropyl-4-(4-methoxy-phenyl)-6-oxo-5-oxa-10-azabicyclo[7.1.0]decane-10-sulfonic acid 2,2,2-trichloro-ethyl ester

There total 2 articles about (1S,3S,4R,7S,9R)-3,7-diisopropyl-4-(4-methoxy-phenyl)-6-oxo-5-oxa-10-azabicyclo[7.1.0]decane-10-sulfonic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: (3S,8S,9R)-3,8-diisopropyl-9-(4-methoxy-phenyl)-4,7,8,9-tetrahydro-3H-oxonin-2-one

: 69226-51-3
2,2,2-trichloroethyl sulfamate

: 1200341-39-4
(1S,3S,4R,7S,9R)-3,7-diisopropyl-4-(4-methoxy-phenyl)-6-oxo-5-oxa-10-azabicyclo[7.1.0]decane-10-sulfonic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: With tetrakis(μ-trifluoroacetamidato)dirhodium(II); [bis(acetoxy)iodo]benzene; magnesium oxide; In toluene; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol100427v

Reference yield:

: C₂₃H₃₄O₃

: 1200341-39-4
(1S,3S,4R,7S,9R)-3,7-diisopropyl-4-(4-methoxy-phenyl)-6-oxo-5-oxa-10-azabicyclo[7.1.0]decane-10-sulfonic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Grubbs catalyst first generation; titanium(IV) isopropylate / toluene / 78 h / 20 °C / Inert atmosphere

2: magnesium oxide; Rh₂(tfacam)₄; [bis(acetoxy)iodo]benzene / toluene / 16 h / 0 - 25 °C / Inert atmosphere

With Grubbs catalyst first generation; titanium(IV) isopropylate; [bis(acetoxy)iodo]benzene; Rh₂(tfacam)₄; magnesium oxide; In toluene;
DOI:10.1021/jo5015195