C₃₂H₃₈N₂O₃Si

Base Information

• Chemical Name: C₃₂H₃₈N₂O₃Si
• CAS No.: 119184-27-9
• Molecular Formula: C₃₂H₃₈N₂O₃Si
• Molecular Weight: 526.751

Synonyms:C₃₂H₃₈N₂O₃Si

Chemical Property of C₃₂H₃₈N₂O₃Si

Chemical Property:

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Technology Process of C₃₂H₃₈N₂O₃Si

There total 15 articles about C₃₂H₃₈N₂O₃Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,3S)-(+)-methyl 2,9-dibenzyl-3-(methoxycarbonyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole-1-propionate (119184-21-3) → C32H38N2O3Si (119184-27-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 84 percent / NaH / methanol; toluene / 13.5 h / Heating

2: 72 percent / H₂ / 10percent Pd/C / formic acid

3: 86 percent / H₂SO₄ / aq. acetic acid / Heating

4: 89 percent / K₂CO₃ / ethanol

5: 1.) Et₃N, 2.) n-BuLi / 1.) CH₂Cl₂, 0 deg C, 2.) THF, -78 deg C

With n-butyllithium; sulfuric acid; hydrogen; sodium hydride; potassium carbonate; triethylamine; palladium on activated charcoal; In methanol; formic acid; ethanol; acetic acid; toluene;

DOI:10.1021/ja00184a086

Reference yield:

C30H28N2O3 (119184-23-5,119241-71-3) → C32H38N2O3Si (119184-27-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 72 percent / H₂ / 10percent Pd/C / formic acid

2: 86 percent / H₂SO₄ / aq. acetic acid / Heating

3: 89 percent / K₂CO₃ / ethanol

4: 1.) Et₃N, 2.) n-BuLi / 1.) CH₂Cl₂, 0 deg C, 2.) THF, -78 deg C

With n-butyllithium; sulfuric acid; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In formic acid; ethanol; acetic acid;

DOI:10.1021/ja00184a086

Reference yield:

(S)-3-(1-Benzyl-1H-indol-3-yl)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-propionic acid methyl ester (129708-73-2) → (6R,10R)-(+)-methyl 5-benzyl-9-<(tert-butyldimethylsilyl)oxy>-6,7,10,11-tetrahydro-6,10-imino-5H-cyclooctindole-12-but-2-ynoate (119184-27-9)

Guidance literature:

Multi-step reaction with 9 steps

1: 95 percent / sodium borohydride / methanol / 1 h / 25 °C

2: 67 percent / benzene; dioxane / 24 h / Heating

3: chlorotrimethylsilane / 25 °C

4: 72 percent / NaH, MeOH / toluene / 16 h / Heating

5: 99 percent / HOAc, H₂SO₄ / H₂O / 72 h / Heating

6: 85 percent / 88percent aq. formic acid / 10percent Pd/C / 2 h / Ambient temperature

7: 60 percent / K₂CO₃ / ethanol; toluene / 12 h / Ambient temperature

8: 82 percent / Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

9: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 15 min, 2.) from -78 deg C to -30 deg C

With methanol; sodium tetrahydroborate; n-butyllithium; chloro-trimethyl-silane; formic acid; sulfuric acid; sodium hydride; potassium carbonate; acetic acid; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene; benzene;

DOI:10.1021/ja00169a033

upstream raw materials:

(6R,10R)-(+)-5-benzyl-9-<(tert-butyldimethylsilyl)oxy>-12-(prop-2-ynyl)-6,7,10,11-tetrahydro-6,10-imino-5H-cyclooctindole

methyl chloroformate

(6R,10R)-(+)-5-benzyl-9-oxo-12-(prop-2-ynyl)-6,7,8,9,10,11-hexahydro-6,10-imino-5H-cyclooctindole

(S)-3-(1-Benzyl-1H-indol-3-yl)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-propionic acid methyl ester

Downstream raw materials:

(6R,10R)-(+)-methyl 5-benzyl-9-oxy-6,7,10,11-tetrahydro-6,10-imino-5H-cyclooctindole-12-but-2-ynoate

(+)-taberpsychine

(+)-koumine

(E)-(2S,6R,12bR)-(+)-methyl 12-benzyl-13-methylene-18-oxo-18-methoxy-1,2,3,4,5,6,7,12,12b-octahydro-2,6-methanoindolo<2,3-a>quinolizine-3-ethylidenoate

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