(2S)-tert-butyl 2-(2'-cyano-2'-triphenylphosphoranylideneacetyl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: (2S)-tert-butyl 2-(2'-cyano-2'-triphenylphosphoranylideneacetyl)pyrrolidine-1-carboxylate
• CAS No.: 1291070-57-9
• Molecular Formula: C₃₀H₃₁N₂O₃P
• Molecular Weight: 498.562
• Mol file: 1291070-57-9.mol

Synonyms:(2S)-tert-butyl 2-(2'-cyano-2'-triphenylphosphoranylideneacetyl)pyrrolidine-1-carboxylate

Chemical Property of (2S)-tert-butyl 2-(2'-cyano-2'-triphenylphosphoranylideneacetyl)pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-tert-butyl 2-(2'-cyano-2'-triphenylphosphoranylideneacetyl)pyrrolidine-1-carboxylate

There total 1 articles about (2S)-tert-butyl 2-(2'-cyano-2'-triphenylphosphoranylideneacetyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + cyanomethylene triphenylphosphorane (16640-68-9) → (2S)-tert-butyl 2-(2'-cyano-2'-triphenylphosphoranylideneacetyl)pyrrolidine-1-carboxylate (1291070-57-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 20h; Inert atmosphere; Cooling with ice;

DOI:10.1016/j.tetasy.2011.01.025

Reference yield:

(2S)-tert-butyl 2-(2'-cyano-2'-triphenylphosphoranylideneacetyl)pyrrolidine-1-carboxylate (1291070-57-9) → C22H28F3NO7 (1291070-61-5)

Guidance literature:

Multi-step reaction with 3 steps

1: ozone / dichloromethane / 0.67 h / -78 °C

2: zinc(II) tetrahydroborate / tetrahydrofuran; diethyl ether / 4 h / -78 °C / Inert atmosphere

3: pyridine / 10 h

With pyridine; zinc(II) tetrahydroborate; ozone; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1016/j.tetasy.2011.01.025

Reference yield:

(2S)-tert-butyl 2-(2'-cyano-2'-triphenylphosphoranylideneacetyl)pyrrolidine-1-carboxylate (1291070-57-9) → C22H28F3NO7 (1291070-62-6)

Guidance literature:

Multi-step reaction with 3 steps

1: ozone / dichloromethane / 0.67 h / -78 °C

2: zinc(II) tetrahydroborate / tetrahydrofuran; diethyl ether / 4 h / -78 °C / Inert atmosphere

3: pyridine / 10 h

With pyridine; zinc(II) tetrahydroborate; ozone; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1016/j.tetasy.2011.01.025

upstream raw materials:

1-(tert-butoxycarbonyl)-L-proline

cyanomethylene triphenylphosphorane

Downstream raw materials:

C₂₂H₂₈F₃NO₇

C₂₂H₂₈F₃NO₇

C₂₂H₂₈F₃NO₇

C₂₂H₂₈F₃NO₇