Hydrazine, [3-(methylsulfonyl)phenyl]- (9CI)

Base Information

• Chemical Name: Hydrazine, [3-(methylsulfonyl)phenyl]- (9CI)
• CAS No.: 312303-93-8
• Molecular Formula: C7H10 N2 O2 S
• Molecular Weight: 186.235
• Mol file: 312303-93-8.mol

Synonyms:(3-Methanesulfonylphenyl)hydrazine

Chemical Property of Hydrazine, [3-(methylsulfonyl)phenyl]- (9CI)

Chemical Property:

• Boiling Point: 435.5±37.0 °C(Predicted)
• PKA: 4.43±0.10(Predicted)
• PSA: 80.57000
• Density: 1.351
• LogP: 2.22980

Purity/Quality:

97% ^*data from raw suppliers

(3-Methanesulfonylphenyl)hydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Hydrazine, [3-(methylsulfonyl)phenyl]- (9CI)

There total 2 articles about Hydrazine, [3-(methylsulfonyl)phenyl]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methylsulfonylaniline hydrochloride (80213-28-1) → (3-(methylsulfonyl)phenyl)hydrazine (312303-93-8)

Guidance literature:

3-methylsulfonylaniline hydrochloride; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;

With hydrogenchloride; tin(ll) chloride; In water; at 0 ℃; for 1h;

With sodium hydroxide; In water;

Reference yield:

3-methylmercaptoaniline (1783-81-9) → (3-(methylsulfonyl)phenyl)hydrazine (312303-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. Oxone^TM / methanol

2: NaNO₂; aq. HCl; SnCl₂

With hydrogenchloride; Oxone; tin(ll) chloride; sodium nitrite; In methanol;

DOI:10.1016/j.bmcl.2004.06.075

Reference yield:

2,4,6-trichloropyrimidine-5-carbaldehyde (50270-27-4) + (3-(methylsulfonyl)phenyl)hydrazine (312303-93-8) → 4,6-dichloro-1-(3-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidine

Guidance literature:

With triethylamine; In tetrahydrofuran; water; at -78 - -10 ℃; for 1.5h;

upstream raw materials:

3-methylsulfonylaniline hydrochloride

3-methylmercaptoaniline

Downstream raw materials:

5-amino-1-(3-methanesulfonyl-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester