N₄-allyl-N₂-(3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₄-allyl-N₂-(3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine
• CAS No.: 1356010-50-8
• Molecular Formula: C₂₈H₂₈FN₇O
• Molecular Weight: 497.575

Synonyms:N₄-allyl-N₂-(3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Chemical Property of N₄-allyl-N₂-(3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Chemical Property:

Purity/Quality:

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Technology Process of N₄-allyl-N₂-(3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

There total 11 articles about N₄-allyl-N₂-(3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)aniline (1356009-07-8) + N-allyl-2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine (1356009-80-7) → N4-allyl-N2-(3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1356010-50-8)

Guidance literature:

at 150 ℃; for 0.75h;

Reference yield:

cyclopentanone (120-92-3) → N4-allyl-N2-(3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1356010-50-8)

Guidance literature:

Multi-step reaction with 7 steps

1: diethyl ether; tetrahydrofuran / 2 h / 0 °C / Reflux

2: formic acid; dihydrogen peroxide / 20 - 50 °C

3: 3 h / 58 - 130 °C

4: ammonium hydroxide / 100 °C

5: trichlorophosphate; N,N-dimethyl-aniline / 110 °C

6: N-ethyl-N,N-diisopropylamine / acetonitrile / 18 h / 20 °C

7: 0.75 h / 150 °C

With ammonium hydroxide; formic acid; dihydrogen peroxide; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; diethyl ether; acetonitrile;

Reference yield:

3,4-difluoronitrobenzene (369-34-6) → N4-allyl-N2-(3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1356010-50-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / dimethyl sulfoxide / 48 h / 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

2.2: 0.5 h / 20 °C

3.1: ammonium chloride; iron / methanol / 0.83 h / 65 °C

4.1: 0.75 h / 150 °C

With iron; sodium hydride; sodium hydrogencarbonate; ammonium chloride; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

cyclopentanone

3,4-difluoronitrobenzene

4-flourophenylmagnesium bromide

1-cyclopent-1-enyl 4-fluorobenzene

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