2-amino-6-chloro-9-[β-D-2‘-deoxy-ribofuranosyl]-7-(2-nitrobenzyloxy)methyl-7-deazapurine

Base Information

Chemical Name:2-amino-6-chloro-9-[β-D-2‘-deoxy-ribofuranosyl]-7-(2-nitrobenzyloxy)methyl-7-deazapurine
CAS No.:1200461-88-6
Molecular Formula:C₁₉H₂₀ClN₅O₆
Molecular Weight:449.851
Hs Code.:

Synonyms:2-amino-6-chloro-9-[β-D-2‘-deoxy-ribofuranosyl]-7-(2-nitrobenzyloxy)methyl-7-deazapurine

Suppliers and Price of 2-amino-6-chloro-9-[β-D-2‘-deoxy-ribofuranosyl]-7-(2-nitrobenzyloxy)methyl-7-deazapurine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-amino-6-chloro-9-[β-D-2‘-deoxy-ribofuranosyl]-7-(2-nitrobenzyloxy)methyl-7-deazapurine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-amino-6-chloro-9-[β-D-2‘-deoxy-ribofuranosyl]-7-(2-nitrobenzyloxy)methyl-7-deazapurine

There total 5 articles about 2-amino-6-chloro-9-[β-D-2‘-deoxy-ribofuranosyl]-7-(2-nitrobenzyloxy)methyl-7-deazapurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1200461-86-4
9-[β-D-3’,5’-O-bis-(tert-butyldimethylsilyl)-2’-deoxyribofuranosyl]-2-(tert-butyldimethylsilyl)amino-6-chloro-7-(2-nitrobenzyloxy)methyl-7-deazapurine

: 1200461-88-6
2-amino-6-chloro-9-[β-D-2‘-deoxy-ribofuranosyl]-7-(2-nitrobenzyloxy)methyl-7-deazapurine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;
DOI:10.1002/anie.201106516

Reference yield:

: 1200461-78-4
C₁₁H₁₂ClIN₄O₃

: 1200461-88-6
2-amino-6-chloro-9-[β-D-2‘-deoxy-ribofuranosyl]-7-(2-nitrobenzyloxy)methyl-7-deazapurine

Guidance literature:: Multi-step reaction with 5 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 48 h / 50 °C

2: bis(benzonitrile)palladium(II) dichloride; triethylamine / 1,4-dioxane / 24 h / 58 °C

3: lithium borohydride / tetrahydrofuran; methanol / 1 h / Reflux

4: tetrabutylammomium bromide; sodium hydroxide / dichloromethane / 48 h / 20 °C / Darkness

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C

With 1H-imidazole; bis(benzonitrile)palladium(II) dichloride; lithium borohydride; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/anie.201106516

Reference yield:

: 1200461-80-8
9-[β-D-3’,5’-O-bis-(tert-butyldimethylsilyl)-2’-deoxyribofuranosyl]-2-(tert-butyldimethylsilyl)amino-6-chloro-7-iodo-7-deazapurine

: 1200461-88-6
2-amino-6-chloro-9-[β-D-2‘-deoxy-ribofuranosyl]-7-(2-nitrobenzyloxy)methyl-7-deazapurine

Guidance literature:: Multi-step reaction with 4 steps

1: bis(benzonitrile)palladium(II) dichloride; triethylamine / 1,4-dioxane / 24 h / 58 °C

2: lithium borohydride / tetrahydrofuran; methanol / 1 h / Reflux

3: tetrabutylammomium bromide; sodium hydroxide / dichloromethane / 48 h / 20 °C / Darkness

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C

With bis(benzonitrile)palladium(II) dichloride; lithium borohydride; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1002/anie.201106516