(R)-N-(1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-4-(1,2-dihydroxypropan-2-yl)benzamide

Base Information

Chemical Name:(R)-N-(1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-4-(1,2-dihydroxypropan-2-yl)benzamide
CAS No.:1324003-35-1
Molecular Formula:C₂₀H₂₁N₃O₃
Molecular Weight:351.405
Hs Code.:

Synonyms:(R)-N-(1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-4-(1,2-dihydroxypropan-2-yl)benzamide

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Chemical Property of (R)-N-(1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-4-(1,2-dihydroxypropan-2-yl)benzamide

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Technology Process of (R)-N-(1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-4-(1,2-dihydroxypropan-2-yl)benzamide

There total 3 articles about (R)-N-(1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-4-(1,2-dihydroxypropan-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1324003-18-0
N-(1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-4-(prop-1-en-2-yl)benzamide

: 1324003-35-1
(R)-N-(1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-4-(1,2-dihydroxypropan-2-yl)benzamide

Guidance literature:: With methanesulfonamide; AD-mix β; water; In tert-butyl alcohol; for 3.5h; Cooling with ice;

Reference yield:

: 74976-31-1
6-chloro-1H-pyrrolo[3,2-c]pyridine

: 1324003-35-1
(R)-N-(1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-4-(1,2-dihydroxypropan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / [2,2]bipyridinyl; copper diacetate / 1,2-dichloro-ethane / 70 °C

2: potassium phosphate / palladium diacetate; 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl / 1,4-dioxane; tert-butyl alcohol / 24 h / 130 °C / Inert atmosphere; Sealed vessel

3: water; methanesulfonamide; AD-mix β / tert-butyl alcohol / 3.5 h / Cooling with ice

With potassium phosphate; methanesulfonamide; AD-mix β; water; sodium carbonate; 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; [2,2]bipyridinyl; copper diacetate; palladium diacetate; In 1,4-dioxane; 1,2-dichloro-ethane; tert-butyl alcohol;

Reference yield:

: 1324003-17-9
6-chloro-1-cyclopropyl-1H-pyrrolo[3,2-c]pyridine

: 1324003-35-1
(R)-N-(1-cyclopropyl-1H-pyrrolo[3,2-c]pyridin-6-yl)-4-(1,2-dihydroxypropan-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / palladium diacetate; 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl / 1,4-dioxane; tert-butyl alcohol / 24 h / 130 °C / Inert atmosphere; Sealed vessel

2: water; methanesulfonamide; AD-mix β / tert-butyl alcohol / 3.5 h / Cooling with ice

With potassium phosphate; methanesulfonamide; AD-mix β; water; 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; palladium diacetate; In 1,4-dioxane; tert-butyl alcohol;