4-(4-Chloro-2-phenylacetylamino-phenyl)-4-hydroxy-butyric acid ethyl ester

Base Information

Chemical Name:4-(4-Chloro-2-phenylacetylamino-phenyl)-4-hydroxy-butyric acid ethyl ester
CAS No.:150097-79-3
Molecular Formula:C₂₀H₂₂ClNO₄
Molecular Weight:375.852
Hs Code.:

Synonyms:4-(4-Chloro-2-phenylacetylamino-phenyl)-4-hydroxy-butyric acid ethyl ester

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Chemical Property of 4-(4-Chloro-2-phenylacetylamino-phenyl)-4-hydroxy-butyric acid ethyl ester

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Technology Process of 4-(4-Chloro-2-phenylacetylamino-phenyl)-4-hydroxy-butyric acid ethyl ester

There total 4 articles about 4-(4-Chloro-2-phenylacetylamino-phenyl)-4-hydroxy-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 27374-25-0
[(1-Ethoxycyclopropyl)oxy]trimethylsilane

: 150097-78-2
2-(Benzylcarbonylamino)-4-chloro benzaldehyde

: 150097-79-3
4-(4-Chloro-2-phenylacetylamino-phenyl)-4-hydroxy-butyric acid ethyl ester

Guidance literature:: With titanium tetrachloride; In dichloromethane; a) -78 deg C, 15 min, b) 0 deg C, 45 min, c) RT, 3 h;
DOI:10.1021/jm9605492

Reference yield:

: 37585-16-3
(2-amino-4-chlorophenyl)methanol

: 150097-79-3
4-(4-Chloro-2-phenylacetylamino-phenyl)-4-hydroxy-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

2: aq. NaOH / methanol / 0.75 h / 50 °C

3: pyridinium chloroformate, 4 Angstroem molecular sieves / CH₂Cl₂ / 1.5 h / Ambient temperature

4: 54 percent / TiCl₄ / CH₂Cl₂ / a) -78 deg C, 15 min, b) 0 deg C, 45 min, c) RT, 3 h

With sodium hydroxide; pyridinium chloroformate; 4 A molecular sieve; titanium tetrachloride; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm9605492

Reference yield:

: 150097-77-1
N-(Benzylcarbonyl)-5-chloro-2-hydroxymethylaniline

: 150097-79-3
4-(4-Chloro-2-phenylacetylamino-phenyl)-4-hydroxy-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium chloroformate, 4 Angstroem molecular sieves / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 54 percent / TiCl₄ / CH₂Cl₂ / a) -78 deg C, 15 min, b) 0 deg C, 45 min, c) RT, 3 h

With pyridinium chloroformate; 4 A molecular sieve; titanium tetrachloride; In dichloromethane;
DOI:10.1021/jm9605492