C₁₉H₁₂F₂N₆O₂

Base Information

Chemical Name:C₁₉H₁₂F₂N₆O₂
CAS No.:1372148-95-2
Molecular Formula:C₁₉H₁₂F₂N₆O₂
Molecular Weight:394.34
Hs Code.:

C<sub>19</sub>H<sub>12</sub>F<sub>2</sub>N<sub>6</sub>O<sub>2</sub>

Synonyms:C₁₉H₁₂F₂N₆O₂

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Chemical Property of C₁₉H₁₂F₂N₆O₂

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Technology Process of C₁₉H₁₂F₂N₆O₂

There total 6 articles about C₁₉H₁₂F₂N₆O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1372148-91-8
C₂₀H₁₅F₂N₃O₄S

: 1372148-95-2
C₁₉H₁₂F₂N₆O₂

Guidance literature:: With sodium azide; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 4h;
DOI:10.1055/s-0031-1290079

Reference yield:

: 1372148-86-1
C₁₅H₁₀Cl₂F₂N₂OS

: 1372148-95-2
C₁₉H₁₂F₂N₆O₂

Guidance literature:: Multi-step reaction with 4 steps

1: potassium phosphate / dimethyl sulfoxide / 0.5 h / 100 °C

2: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; triethylamine / 1,4-dioxane / 5 h / Reflux

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 21 h / 20 °C

4: sodium azide / tetrahydrofuran; dimethyl sulfoxide / 4 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; sodium azide; palladium diacetate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide; 2: Suzuki-Miyaura coupling;
DOI:10.1055/s-0031-1290079

Reference yield:

: 412018-50-9
1-(4,6-dichloropyridin-3-yl)ethan-1-one

: 1372148-95-2
C₁₉H₁₂F₂N₆O₂

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -40 °C / Inert atmosphere

1.2: 1.5 h / -40 - 20 °C

1.3: 0.33 h / 5 - 20 °C

2.1: potassium phosphate / dimethyl sulfoxide / 0.5 h / 100 °C

3.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; triethylamine / 1,4-dioxane / 5 h / Reflux

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 21 h / 20 °C

5.1: sodium azide / tetrahydrofuran; dimethyl sulfoxide / 4 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; sodium azide; palladium diacetate; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide; 3.1: Suzuki-Miyaura coupling;
DOI:10.1055/s-0031-1290079