N-Boc-2-[(4'-4-trifluoromethoxybiphenyl-4-sulfonylamino)methyl]-1-bromonaphthalene

Base Information

Chemical Name:N-Boc-2-[(4'-4-trifluoromethoxybiphenyl-4-sulfonylamino)methyl]-1-bromonaphthalene
CAS No.:279246-03-6
Molecular Formula:C₂₉H₂₅BrF₃NO₅S
Molecular Weight:636.486
Hs Code.:

Synonyms:N-Boc-2-[(4'-4-trifluoromethoxybiphenyl-4-sulfonylamino)methyl]-1-bromonaphthalene

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Chemical Property of N-Boc-2-[(4'-4-trifluoromethoxybiphenyl-4-sulfonylamino)methyl]-1-bromonaphthalene

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Technology Process of N-Boc-2-[(4'-4-trifluoromethoxybiphenyl-4-sulfonylamino)methyl]-1-bromonaphthalene

There total 6 articles about N-Boc-2-[(4'-4-trifluoromethoxybiphenyl-4-sulfonylamino)methyl]-1-bromonaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 76635-70-6
(1-bromo-2-naphthyl)methanol

: 279246-02-5
N-Boc-4'-trifluoromethoxybiphenyl-4-sulfonamide

: 279246-03-6
N-Boc-2-[(4'-4-trifluoromethoxybiphenyl-4-sulfonylamino)methyl]-1-bromonaphthalene

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 24h;
DOI:10.1021/jm020160g

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 279246-03-6
N-Boc-2-[(4'-4-trifluoromethoxybiphenyl-4-sulfonylamino)methyl]-1-bromonaphthalene

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Et₃N; DMAP / CH₂Cl₂ / 12 h / 20 °C

2: 88 percent / 2M aq. Na₂CO₃; tetrakis(triphenylphosphine)palladium / ethanol; toluene / 1.25 h / Heating

3: 89 percent / Ph₃P; DEAD / tetrahydrofuran / 24 h

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; toluene; 2: Suzuki coupling / 3: Mitsunobu reaction;
DOI:10.1021/jm020160g

Reference yield:

: 3378-82-3
1-bromo-2-naphthaldehyde

: 279246-03-6
N-Boc-2-[(4'-4-trifluoromethoxybiphenyl-4-sulfonylamino)methyl]-1-bromonaphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / NaBH₄ / methanol / 0.25 h / 0 °C

2: 89 percent / Ph₃P; DEAD / tetrahydrofuran / 24 h

With sodium tetrahydroborate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; 2: Mitsunobu reaction;
DOI:10.1021/jm020160g