(4R,5R)-1-(tert-butyloxycarbonyl)-4-(4-chlorophenyl)-5--2-piperidone

Base Information

Chemical Name:(4R,5R)-1-(tert-butyloxycarbonyl)-4-(4-chlorophenyl)-5--2-piperidone
CAS No.:229182-28-9
Molecular Formula:C₂₃H₂₄ClNO₅S
Molecular Weight:461.966
Hs Code.:

(4R,5R)-1-(tert-butyloxycarbonyl)-4-(4-chlorophenyl)-5-<O-(phenyloxythiocarbonyl)hydroxy>-2-piperidone

Synonyms:(4R,5R)-1-(tert-butyloxycarbonyl)-4-(4-chlorophenyl)-5--2-piperidone

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Chemical Property of (4R,5R)-1-(tert-butyloxycarbonyl)-4-(4-chlorophenyl)-5--2-piperidone

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Technology Process of (4R,5R)-1-(tert-butyloxycarbonyl)-4-(4-chlorophenyl)-5--2-piperidone

There total 1 articles about (4R,5R)-1-(tert-butyloxycarbonyl)-4-(4-chlorophenyl)-5--2-piperidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1005-56-7
phenylcarbonochloridothioate

: (4R,5R)-4-(4-Chloro-phenyl)-5-hydroxy-2-oxo-piperidine-1-carboxylic acid tert-butyl ester

: 229182-28-9
(4R,5R)-1-(tert-butyloxycarbonyl)-4-(4-chlorophenyl)-5--2-piperidone

Guidance literature:: With dmap; In dichloromethane; at 25 ℃; for 18h;
DOI:10.1021/jm990076+

Reference yield: 94.0%

: 229182-28-9
(4R,5R)-1-(tert-butyloxycarbonyl)-4-(4-chlorophenyl)-5--2-piperidone

: 229182-29-0
(R)-1-(tert-butyloxycarbonyl)-4-(4-chlorophenyl)-2-piperidinone

Guidance literature:: With di-tert-butyl diperoxyoxalate; tri-n-butyl-tin hydride; In acetone; at 25 ℃; for 18h;
DOI:10.1021/jm990076+

Reference yield:

: 229182-28-9
(4R,5R)-1-(tert-butyloxycarbonyl)-4-(4-chlorophenyl)-5--2-piperidone

: 229182-32-5
(R)-5--3-(4-chlorophenyl)pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / SnBu₃H, di-tert-butyl peroxyoxalate / acetone / 18 h / 25 °C

2: 64 percent / aq. LiOH / tetrahydrofuran / 2 h

With lithium hydroxide; di-tert-butyl diperoxyoxalate; tri-n-butyl-tin hydride; In tetrahydrofuran; acetone;
DOI:10.1021/jm990076+