2-(4-{5-[(tert-butoxycarbonyl)amino]pentanoyl}piperazin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate

Base Information

• Chemical Name: 2-(4-{5-[(tert-butoxycarbonyl)amino]pentanoyl}piperazin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate
• CAS No.: 566906-17-0
• Molecular Formula: C₂₄H₃₇ClN₄O₆
• Molecular Weight: 513.034
• Mol file: 566906-17-0.mol

Synonyms:2-(4-{5-[(tert-butoxycarbonyl)amino]pentanoyl}piperazin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate

Chemical Property of 2-(4-{5-[(tert-butoxycarbonyl)amino]pentanoyl}piperazin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-{5-[(tert-butoxycarbonyl)amino]pentanoyl}piperazin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate

There total 1 articles about 2-(4-{5-[(tert-butoxycarbonyl)amino]pentanoyl}piperazin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

5-(N-tert-butyloxycarbonyl)aminopentanoic acid (27219-07-4) + 2-[N-piperazin-1-yl]ethyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride → 2-(4-{5-[(tert-butoxycarbonyl)amino]pentanoyl}piperazin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate (566906-17-0)

Guidance literature:

5-(N-tert-butyloxycarbonyl)aminopentanoic acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In acetonitrile; at 0 ℃;

2-[N-piperazin-1-yl]ethyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride; In acetonitrile; at 20 ℃; for 24h;

DOI:10.1021/jm0307887

Reference yield: 53.0%

2-(4-{5-[(tert-butoxycarbonyl)amino]pentanoyl}piperazin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate (566906-17-0) → 2-[4-(5-aminopentanoyl)piperazin-1-yl]ethyl 4-amino-5-chloro-2-methoxybenzoate dihydrochloride

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃;

DOI:10.1021/jm0307887

Reference yield:

2-(4-{5-[(tert-butoxycarbonyl)amino]pentanoyl}piperazin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate (566906-17-0) → 2-{4-[5-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)pentanoyl]piperazin-1-yl}ethyl 4-amino-5-chloro-2-methoxybenzoate

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / HCl / methanol / 20 °C

2: 58 percent / Et₃N / CH₂Cl₂ / 6 h / -10 - 0 °C

With hydrogenchloride; triethylamine; In methanol; dichloromethane;

DOI:10.1021/jm0307887

upstream raw materials:

5-(N-tert-butyloxycarbonyl)aminopentanoic acid