2-{(S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-piperazin-2-yl}-N-(tetrahydropyran-4-ylmethyl)-acetamide hydrochloride

Base Information

Chemical Name:2-{(S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-piperazin-2-yl}-N-(tetrahydropyran-4-ylmethyl)-acetamide hydrochloride
CAS No.:1262891-94-0
Molecular Formula:C₃₅H₃₉FN₄O₃*ClH
Molecular Weight:619.179
Hs Code.:

Synonyms:2-{(S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-piperazin-2-yl}-N-(tetrahydropyran-4-ylmethyl)-acetamide hydrochloride

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Chemical Property of 2-{(S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-piperazin-2-yl}-N-(tetrahydropyran-4-ylmethyl)-acetamide hydrochloride

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Technology Process of 2-{(S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-piperazin-2-yl}-N-(tetrahydropyran-4-ylmethyl)-acetamide hydrochloride

There total 19 articles about 2-{(S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-piperazin-2-yl}-N-(tetrahydropyran-4-ylmethyl)-acetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262891-97-3
(S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-2-{[(tetrahydropyran-4-ylmethyl)-carbamoyl]-methyl}-piperazine-1-carboxylic acid tert-butyl ester

: 1262891-94-0
2-{(S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-piperazin-2-yl}-N-(tetrahydropyran-4-ylmethyl)-acetamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 3.5h;

Reference yield:

: 477220-33-0,517866-77-2
2-[(2S)-4-benzylpiperazin-2-yl]ethanol

: 1262891-94-0
2-{(S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-piperazin-2-yl}-N-(tetrahydropyran-4-ylmethyl)-acetamide hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: dichloromethane / 20 °C

2: hydrogen / 20% palladium hydroxide on carbon / ethanol / 20 °C / 3000.3 Torr

3: 1H-imidazole / dichloromethane / 3 h / 20 °C

4: pyridine / dichloromethane; toluene / 0 - 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

6: Dess-Martin periodane / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

7: water; sodium chlorite; sodium dihydrogenphosphate / 2-methyl-but-2-ene; tert-butyl alcohol; tetrahydrofuran

8: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / 0 - 20 °C

9: hydrogenchloride / dichloromethane; 1,4-dioxane / 3.5 h / 0 - 20 °C

With pyridine; 1H-imidazole; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; tetrabutyl ammonium fluoride; water; hydrogen; Dess-Martin periodane; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; 20% palladium hydroxide on carbon; In tetrahydrofuran; 1,4-dioxane; 2-methyl-but-2-ene; ethanol; dichloromethane; toluene; tert-butyl alcohol;

Reference yield:

: 169447-92-1
tert-butyl (2S)-4-benzyl-2-(2-hydroxyethyl)piperazine-1-carboxylate

: 1262891-94-0
2-{(S)-4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-indolizine-3-carbonyl]-piperazin-2-yl}-N-(tetrahydropyran-4-ylmethyl)-acetamide hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogen / 20% palladium hydroxide on carbon / ethanol / 20 °C / 3000.3 Torr

2: 1H-imidazole / dichloromethane / 3 h / 20 °C

3: pyridine / dichloromethane; toluene / 0 - 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

5: Dess-Martin periodane / dichloromethane / 3.5 h / 20 °C / Inert atmosphere

6: water; sodium chlorite; sodium dihydrogenphosphate / 2-methyl-but-2-ene; tert-butyl alcohol; tetrahydrofuran

7: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / 0 - 20 °C

8: hydrogenchloride / dichloromethane; 1,4-dioxane / 3.5 h / 0 - 20 °C

With pyridine; 1H-imidazole; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; tetrabutyl ammonium fluoride; water; hydrogen; Dess-Martin periodane; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; 20% palladium hydroxide on carbon; In tetrahydrofuran; 1,4-dioxane; 2-methyl-but-2-ene; ethanol; dichloromethane; toluene; tert-butyl alcohol;