Cyclopentanecarboxylic acid, 1-amino-2-(1-methylethyl)-, (1S,2R)- (9CI)

Base Information

Chemical Name:Cyclopentanecarboxylic acid, 1-amino-2-(1-methylethyl)-, (1S,2R)- (9CI)
CAS No.:309757-12-8
Molecular Formula:C₉H₁₇NO₂
Molecular Weight:171.239
Hs Code.:
Mol file:309757-12-8.mol

Synonyms:Cyclopentanecarboxylic acid, 1-amino-2-(1-methylethyl)-, (1S,2R)- (9CI)

Suppliers and Price of Cyclopentanecarboxylic acid, 1-amino-2-(1-methylethyl)-, (1S,2R)- (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclopentanecarboxylic acid, 1-amino-2-(1-methylethyl)-, (1S,2R)- (9CI)

Chemical Property:

PSA：0.00000
LogP:0.00000

Purity/Quality:

Safty Information:

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Hazard Codes:

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Technology Process of Cyclopentanecarboxylic acid, 1-amino-2-(1-methylethyl)-, (1S,2R)- (9CI)

There total 6 articles about Cyclopentanecarboxylic acid, 1-amino-2-(1-methylethyl)-, (1S,2R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 309757-00-4
(1S,2R)-1-amino-2-(1-methylethyl)cyclopentanecarboxamide

: 309757-12-8
(1S,2R)-1-amino-2-(1-methylethyl)cyclopentanecarboxylic acid

Guidance literature:: With hydrogenchloride; at 80 ℃; for 10h;
DOI:10.1016/S0957-4166(00)00284-6

Reference yield:

: 2-Isopropyl-1-((S)-1-phenyl-ethylamino)-cyclopentanecarbonitrile

: 309757-11-7
(1R,2S)-1-amino-2-(1-methylethyl)cyclopentanecarboxylic acid

: 309757-12-8
(1S,2R)-1-amino-2-(1-methylethyl)cyclopentanecarboxylic acid

: (1R,2R)-1-Amino-2-isopropyl-cyclopentanecarboxylic acid

: (1S,2S)-1-Amino-2-isopropyl-cyclopentanecarboxylic acid

Guidance literature:: 2-Isopropyl-1-((S)-1-phenyl-ethylamino)-cyclopentanecarbonitrile; With sulfuric acid; In dichloromethane; at -5 ℃; for 1344000h;

With ammonium formate; palladium on activated charcoal; In methanol; for 2h; Heating;

With hydrogenchloride; at 80 ℃; for 8h; Title compound not separated from byproducts;

Reference yield:

: 2-(1-methylethyl)-1-(1-phenylethylamino)cyclopentanecarbonitrile

: 309757-12-8
(1S,2R)-1-amino-2-(1-methylethyl)cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: conc. H₂SO₄ / CH₂Cl₂ / 1344000 h / -5 °C

1.2: ammonium formate / Pd/C (10 percent) / methanol / 2 h / Heating

2.1: conc. HCl / 8 h / 80 °C

With hydrogenchloride; sulfuric acid; In dichloromethane;