(R)-tert-butyl 1-(4-(4-methoxybenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate

Base Information

Chemical Name:(R)-tert-butyl 1-(4-(4-methoxybenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate
CAS No.:937248-15-2
Molecular Formula:C₃₃H₃₇N₅O₃
Molecular Weight:551.688
Hs Code.:

Synonyms:(R)-tert-butyl 1-(4-(4-methoxybenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-tert-butyl 1-(4-(4-methoxybenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (R)-tert-butyl 1-(4-(4-methoxybenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate

There total 6 articles about (R)-tert-butyl 1-(4-(4-methoxybenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 937247-85-3
(R)-tert-butyl 1-(4-methoxybenzylamino)-3-(1H-indol-3-yl)-1-thioxopropan-2-ylcarbamate

: 3538-68-9
3-phenylpropanehydrazide

: 937248-15-2
(R)-tert-butyl 1-(4-(4-methoxybenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate

Guidance literature:: With silver benzoate; acetic acid; In dichloromethane; for 12h;
DOI:10.1021/acs.jmedchem.9b02122

Reference yield:

: 956489-58-0
(R)-tert-butyl 1-(4-methoxybenzylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-ylcarbamate

: 937248-15-2
(R)-tert-butyl 1-(4-(4-methoxybenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: Lawesson's reagent / 1,2-dimethoxy-ethane / 2 h / 85 °C

2: mercury(II) acetate / tetrahydrofuran / 48 h / 20 °C

With Lawessons reagent; mercury(II) diacetate; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1021/jm070024h

Reference yield:

: 5241-64-5
Boc-D-Trp-OH

: 937248-15-2
(R)-tert-butyl 1-(4-(4-methoxybenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: (benzotriazol-1-yloxy)-tris(dimethylamino)-phosphonium*PF₆; N-methyl-morpholine / CH₂Cl₂ / 1 h / 20 °C

2: Lawesson's reagent / 1,2-dimethoxy-ethane / 2 h / 85 °C

3: mercury(II) acetate / tetrahydrofuran / 48 h / 20 °C

With Lawessons reagent; 4-methyl-morpholine; mercury(II) diacetate; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jm070024h