tert-butyl 3-(2-(benzyloxy)-2-oxoethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidine-1(6H)-carboxylate

Base Information

Chemical Name:tert-butyl 3-(2-(benzyloxy)-2-oxoethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidine-1(6H)-carboxylate
CAS No.:1354832-37-3
Molecular Formula:C₁₉H₂₂N₂O₆
Molecular Weight:374.393
Hs Code.:

Synonyms:tert-butyl 3-(2-(benzyloxy)-2-oxoethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidine-1(6H)-carboxylate

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Chemical Property of tert-butyl 3-(2-(benzyloxy)-2-oxoethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidine-1(6H)-carboxylate

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Technology Process of tert-butyl 3-(2-(benzyloxy)-2-oxoethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidine-1(6H)-carboxylate

There total 2 articles about tert-butyl 3-(2-(benzyloxy)-2-oxoethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidine-1(6H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 380637-97-8
(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)acetic acid benzyl ester

: 1354832-37-3
tert-butyl 3-(2-(benzyloxy)-2-oxoethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidine-1(6H)-carboxylate

Guidance literature:: With dmap; In tetrahydrofuran; at 0 - 20 ℃; for 18.5h;
DOI:10.1039/c1ob06582c

Reference yield:

: 65-71-4,28806-14-6,691841-57-3
thymin

: 5437-45-6
Benzyl bromoacetate

: 1354832-37-3
tert-butyl 3-(2-(benzyloxy)-2-oxoethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidine-1(6H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: dmap / tetrahydrofuran / 0 - 20 °C

With dmap; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1354832-37-3
tert-butyl 3-(2-(benzyloxy)-2-oxoethyl)-5-methyl-2,6-dioxo-2,3-dihydropyrimidine-1(6H)-carboxylate

: C₃₈H₄₀N₄O₉

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / methanol; acetone / 2 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18.5 h / 0 - 20 °C

With palladium on activated charcoal; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; acetone;
DOI:10.1039/c1ob06582c