2-[(R)-methoxycarbonylamino-(3-trifluoromethyl-phenyl)-methyl]-3-oxo-butyric acid allyl ester

Base Information

• Chemical Name: 2-[(R)-methoxycarbonylamino-(3-trifluoromethyl-phenyl)-methyl]-3-oxo-butyric acid allyl ester
• CAS No.: 865086-61-9
• Molecular Formula: C₁₇H₁₈F₃NO₅
• Molecular Weight: 373.329
• Mol file: 865086-61-9.mol

Synonyms:2-[(R)-methoxycarbonylamino-(3-trifluoromethyl-phenyl)-methyl]-3-oxo-butyric acid allyl ester

Chemical Property of 2-[(R)-methoxycarbonylamino-(3-trifluoromethyl-phenyl)-methyl]-3-oxo-butyric acid allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(R)-methoxycarbonylamino-(3-trifluoromethyl-phenyl)-methyl]-3-oxo-butyric acid allyl ester

There total 2 articles about 2-[(R)-methoxycarbonylamino-(3-trifluoromethyl-phenyl)-methyl]-3-oxo-butyric acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ 2-[(R)-methoxycarbonylamino-(3-trifluoromethyl-phenyl)-methyl]-3-oxo-butyric acid allyl ester (865086-61-9)

Guidance literature:

Reference yield:

[1-(3-Trifluoromethyl-phenyl)-meth-(E)-ylidene]-carbamic acid methyl ester + allyl acetoacetate (1118-84-9) → 2-[(S)-methoxycarbonylamino-(3-trifluoromethyl-phenyl)-methyl]-3-oxo-butyric acid allyl ester + 2-[(R)-methoxycarbonylamino-(3-trifluoromethyl-phenyl)-methyl]-3-oxo-butyric acid allyl ester (865086-61-9)

Guidance literature:

With Cinchonin; In dichloromethane; at -35 ℃; for 16h; Title compound not separated from byproducts;

DOI:10.1021/ja0537373

Reference yield: 83.0%

2-[(R)-methoxycarbonylamino-(3-trifluoromethyl-phenyl)-methyl]-3-oxo-butyric acid allyl ester (865086-61-9) → (R)-[3-oxo-1-(3-trifluoromethyl-phenyl)-butyl]-carbamic acid methyl ester

Guidance literature:

bis(η3-allyl-μ-chloropalladium(II)); 4,5-bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane; acetoacetic acid methyl ester; In dichloromethane; at 20 ℃; for 3.16667h; Product distribution / selectivity;

upstream raw materials:

allyl acetoacetate