(3S)-3-(4-{[(1R)-4-Cyclopropyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol

Base Information

Chemical Name:(3S)-3-(4-{[(1R)-4-Cyclopropyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol
CAS No.:1202578-24-2
Molecular Formula:C₂₃H₂₈O₃
Molecular Weight:352.474
Hs Code.:

Synonyms:(3S)-3-(4-{[(1R)-4-Cyclopropyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol

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Chemical Property of (3S)-3-(4-{[(1R)-4-Cyclopropyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol

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Technology Process of (3S)-3-(4-{[(1R)-4-Cyclopropyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol

There total 10 articles about (3S)-3-(4-{[(1R)-4-Cyclopropyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1202578-23-1
(1S)-4-Cyclopropylindan-1-ol

: 1202577-78-3
4-{(1S)-1-ethoxy-3-[(triisopropylsilyl)oxy]propyl}phenol

: 1202578-24-2
(3S)-3-(4-{[(1R)-4-Cyclopropyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol

Guidance literature:: (1S)-4-Cyclopropylindan-1-ol; 4-{(1S)-1-ethoxy-3-[(triisopropylsilyl)oxy]propyl}phenol; With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 - 50 ℃; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 40 ℃; Inert atmosphere;

Reference yield:

: C₃₂H₄₈O₃Si

: 1202578-24-2
(3S)-3-(4-{[(1R)-4-Cyclopropyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 40 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2015.07.028

Reference yield:

: 1202577-75-0
(1S)-1-(4-benzyloxyphenyl)propan-1,3-diol

: 1202578-24-2
(3S)-3-(4-{[(1R)-4-Cyclopropyl-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.1: hydrogen / Raney nickel / tetrahydrofuran / 14 h / 20 °C

4.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 - 50 °C / Inert atmosphere

4.2: 0 - 40 °C / Inert atmosphere

With 1H-imidazole; hydrogen; sodium hydride; triphenylphosphine; diethylazodicarboxylate; Raney nickel; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;