1H-Pyrrole-3-carboxylicacid,2,5-dihydro-4-methoxy-2,5-dioxo-,methylester(9CI)

Base Information

• Chemical Name: 1H-Pyrrole-3-carboxylicacid,2,5-dihydro-4-methoxy-2,5-dioxo-,methylester(9CI)
• CAS No.: 308815-50-1
• Molecular Formula: C₇H₇NO₅
• Molecular Weight: 185.136
• Mol file: 308815-50-1.mol

Synonyms:1H-Pyrrole-3-carboxylicacid,2,5-dihydro-4-methoxy-2,5-dioxo-,methylester(9CI)

Chemical Property of 1H-Pyrrole-3-carboxylicacid,2,5-dihydro-4-methoxy-2,5-dioxo-,methylester(9CI)

Chemical Property:

• PSA: 81.70000
• LogP: -0.95490

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrole-3-carboxylicacid,2,5-dihydro-4-methoxy-2,5-dioxo-,methylester(9CI)

There total 2 articles about 1H-Pyrrole-3-carboxylicacid,2,5-dihydro-4-methoxy-2,5-dioxo-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + Dimethyl oxalate (553-90-2) + methyl malonamate (51513-29-2) → methyl 4-methoxy-2,5-dioxo-3-pyrroline-3-carboxylate (308815-50-1)

Guidance literature:

Dimethyl oxalate; methyl malonamate; With sodium methylate; In methanol; Heating;

diazomethane; In diethyl ether;

DOI:10.1002/jhet.5570370428

Reference yield: 52.0%

5-benzylidene-2,5-dihydro-4-methoxy-2-oxo-1H-pyrrole-3-carboxylic acid methyl ester (79208-32-5) → methyl 4-methoxy-2,5-dioxo-3-pyrroline-3-carboxylate (308815-50-1)

Guidance literature:

With ozone; In dichloromethane; at -15 ℃; for 0.0666667h;

DOI:10.1002/hlca.200690101

upstream raw materials:

diazomethane

Dimethyl oxalate

methyl malonamate

5-benzylidene-2,5-dihydro-4-methoxy-2-oxo-1H-pyrrole-3-carboxylic acid methyl ester