N-[(Z)-3-(benzothiophen-3-yl)-2-bromoprop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-[(Z)-3-(benzothiophen-3-yl)-2-bromoprop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide
• CAS No.: 1342341-03-0
• Molecular Formula: C₃₁H₃₆BrNO₂S₂
• Molecular Weight: 598.668

Synonyms:N-[(Z)-3-(benzothiophen-3-yl)-2-bromoprop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

Chemical Property of N-[(Z)-3-(benzothiophen-3-yl)-2-bromoprop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

Chemical Property:

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Technology Process of N-[(Z)-3-(benzothiophen-3-yl)-2-bromoprop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide

There total 7 articles about N-[(Z)-3-(benzothiophen-3-yl)-2-bromoprop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide + (Z)-3-(benzothiophen-3-yl)-2-bromoprop-2-en-1-ol (1342341-50-7) → N-[(Z)-3-(benzothiophen-3-yl)-2-bromoprop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide (1342341-03-0)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1055/s-0030-1260098

Reference yield:

benzothiophene-3-carboxaldehyde (5381-20-4) → N-[(Z)-3-(benzothiophen-3-yl)-2-bromoprop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide (1342341-03-0)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / Reflux

2: diisobutylaluminium hydride / tetrahydrofuran; hexane / 0.5 h / Cooling

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

With di-isopropyl azodicarboxylate; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; hexane; toluene;

DOI:10.1055/s-0030-1260098

Reference yield:

methyl (Z)-3-(benzothiophen-3-yl)-2-bromoprop-2-enoate (1342341-48-3) → N-[(Z)-3-(benzothiophen-3-yl)-2-bromoprop-2-enyl]-N-[(1R)-1-cyclohexylhept-2-ynyl]-4-methylbenzenesulfonamide (1342341-03-0)

Guidance literature:

Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 0.5 h / Cooling

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

With di-isopropyl azodicarboxylate; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; hexane;

DOI:10.1055/s-0030-1260098

upstream raw materials:

(Z)-3-(benzothiophen-3-yl)-2-bromoprop-2-en-1-ol

benzothiophene-3-carboxaldehyde

methyl (Z)-3-(benzothiophen-3-yl)-2-bromoprop-2-enoate

hex-1-yne

Downstream raw materials:

(3R)-4-butyl-3-cyclohexyl-2-(4-methylphenylsulfonyl)-2,3-dihydro-1H-benzo[4,5]thieno[2,3-f]isoindole

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