4-[3-[3-(4-fluoro-phenyl)-3-hydroxy-propyl]-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzonitrile

Base Information

• Chemical Name: 4-[3-[3-(4-fluoro-phenyl)-3-hydroxy-propyl]-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzonitrile
• CAS No.: 439080-61-2
• Molecular Formula: C₂₆H₂₃FN₂O₃
• Molecular Weight: 430.479

Synonyms:4-[3-[3-(4-fluoro-phenyl)-3-hydroxy-propyl]-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzonitrile

Chemical Property of 4-[3-[3-(4-fluoro-phenyl)-3-hydroxy-propyl]-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzonitrile

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Technology Process of 4-[3-[3-(4-fluoro-phenyl)-3-hydroxy-propyl]-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzonitrile

There total 1 articles about 4-[3-[3-(4-fluoro-phenyl)-3-hydroxy-propyl]-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[3-[3-(tert-butyl-dimethyl-silanyloxy)-3-(4-fluoro-phenyl)-propyl]-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzonitrile → 4-[3-[3-(4-fluoro-phenyl)-3-hydroxy-propyl]-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzonitrile (439080-61-2)

Guidance literature:

With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 5h; Heating / reflux;

Reference yield:

4-[3-[3-(4-fluoro-phenyl)-3-hydroxy-propyl]-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzonitrile (439080-61-2) → 1-(4-aminomethyl-phenyl)-3-[3-(4-fluoro-phenyl)-3-hydroxy-propyl]-4-(4-methoxy-phenyl)-azetidin-2-one (439080-62-3)

Guidance literature:

With ammonia; hydrogen; In ethanol; water; at 60 ℃; for 8h; under 7500.75 Torr;

Reference yield:

4-[3-[3-(4-fluoro-phenyl)-3-hydroxy-propyl]-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzonitrile (439080-61-2) → 4-[3-[3-(4-fluoro-phenyl)-3-hydroxy-propyl]-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-N-hydroxy-benzamidine

Guidance literature:

With hydroxylamine hydrochloride; triethylamine; In isopropyl alcohol; at 20 ℃; for 12h;

Downstream raw materials:

1-(4-aminomethyl-phenyl)-3-[3-(4-fluoro-phenyl)-3-hydroxy-propyl]-4-(4-methoxy-phenyl)-azetidin-2-one

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