(Z)-methyl 2-(6-(4-(trifluoromethyl)phenyl)hexa-3-en-1,5-diyn-1-yl)benzoate

Base Information

Chemical Name:(Z)-methyl 2-(6-(4-(trifluoromethyl)phenyl)hexa-3-en-1,5-diyn-1-yl)benzoate
CAS No.:1130141-02-4
Molecular Formula:C₂₁H₁₃F₃O₂
Molecular Weight:354.328
Hs Code.:

Synonyms:(Z)-methyl 2-(6-(4-(trifluoromethyl)phenyl)hexa-3-en-1,5-diyn-1-yl)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-methyl 2-(6-(4-(trifluoromethyl)phenyl)hexa-3-en-1,5-diyn-1-yl)benzoate

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Technology Process of (Z)-methyl 2-(6-(4-(trifluoromethyl)phenyl)hexa-3-en-1,5-diyn-1-yl)benzoate

There total 3 articles about (Z)-methyl 2-(6-(4-(trifluoromethyl)phenyl)hexa-3-en-1,5-diyn-1-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1130141-28-4
methyl 2-(3(Z)-6-trimethylsilylhexen-1,5-diynyl)benzoate

: 455-13-0
4-Iodobenzotrifluoride

: 1130141-02-4
(Z)-methyl 2-(6-(4-(trifluoromethyl)phenyl)hexa-3-en-1,5-diyn-1-yl)benzoate

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In methanol; at 20 ℃; for 4h;
DOI:10.1002/adsc.200700516

Reference yield: 69.0%

: 705-31-7
4-trifluoromethylphenylacetylene

: methyl (Z)-2-(4-chlorobut-3-en-1-yn-1-yl)benzoate

: 1130141-02-4
(Z)-methyl 2-(6-(4-(trifluoromethyl)phenyl)hexa-3-en-1,5-diyn-1-yl)benzoate

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-butylamine; In diethyl ether; at 20 ℃; for 6h;
DOI:10.1016/j.tet.2019.01.021

Reference yield:

: 33577-99-0
2-ethynyl-benzoic acid methyl ester

: 1130141-02-4
(Z)-methyl 2-(6-(4-(trifluoromethyl)phenyl)hexa-3-en-1,5-diyn-1-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; N-butylamine / diethyl ether / 6 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; N-butylamine / diethyl ether / 6 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-butylamine; In diethyl ether; 1: |Sonogashira Cross-Coupling / 2: |Sonogashira Cross-Coupling;
DOI:10.1016/j.tet.2019.01.021