(1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 3,5-di(trifluoromethyl)benzoate

Base Information

Chemical Name:(1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 3,5-di(trifluoromethyl)benzoate
CAS No.:1079392-85-0
Molecular Formula:C₂₈H₂₄F₆N₂O₃
Molecular Weight:550.501
Hs Code.:

Synonyms:(1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 3,5-di(trifluoromethyl)benzoate

Suppliers and Price of (1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 3,5-di(trifluoromethyl)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 3,5-di(trifluoromethyl)benzoate

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 3,5-di(trifluoromethyl)benzoate

There total 4 articles about (1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 3,5-di(trifluoromethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1079392-92-9
C₃₇H₄₄F₆N₂O₃Si

: 1079392-85-0,1386986-55-5
(1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 3,5-di(trifluoromethyl)benzoate

Guidance literature:: With hydrogen fluoride; In water; acetonitrile; at 0 ℃; for 0.166667h;
DOI:10.1039/b807640e

Reference yield:

: 130-95-0
Quinine

: 1079392-85-0,1386986-55-5
(1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 3,5-di(trifluoromethyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium thioethylate / N,N-dimethyl-formamide / 24 h / 105 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

3: triethylamine / dichloromethane / 0 - 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; triethylamine; sodium thioethylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/adsc.201701224

Reference yield:

: 524-63-0,70877-75-7
4-[(R)-((2S,4S,5R)-5-ethenyl-1-azabicyclo-[2.2.2]octan-2-yl)(hydroxy)methyl]quinolin-6-ol

: 1079392-85-0,1386986-55-5
(1R)-(6-hydroxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)methyl 3,5-di(trifluoromethyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/adsc.201701224