N1-(2-O-acetyl-3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-thymine

Base Information

Chemical Name:N1-(2-O-acetyl-3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-thymine
CAS No.:161821-89-2
Molecular Formula:C₂₁H₂₅N₂O₁₀P
Molecular Weight:496.411
Hs Code.:

Synonyms:N1-(2-O-acetyl-3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-thymine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N1-(2-O-acetyl-3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-thymine

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Technology Process of N1-(2-O-acetyl-3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-thymine

There total 1 articles about N1-(2-O-acetyl-3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 65-71-4,80289-22-1
2,4-dihydroxy-5-methylpyrimidine

: 161822-02-2
1,2-di-O-acetyl-3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-α-D-ribofuranose

: 161821-89-2
N1-(2-O-acetyl-3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-thymine

Guidance literature:: With chloro-trimethyl-silane; tin(IV) chloride; 1,1,1,3,3,3-hexamethyl-disilazane; In acetonitrile; for 0.5h; Heating;
DOI:10.1016/S0040-4020(01)85564-2

Reference yield: 70.0%

: 161821-89-2
N1-(2-O-acetyl-3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-thymine

: 161821-95-0
N1-(3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-thymine

Guidance literature:: With hydrazine hydrate; In pyridine; acetic acid; for 24h; Ambient temperature;
DOI:10.1016/S0040-4020(01)85564-2

Reference yield:

: 161821-89-2
N1-(2-O-acetyl-3-deoxy-3-C-dimethylphosphono-5-O-benzoyl-β-D-ribofuranosyl)-thymine

: Benzoic acid (2R,3R,4S,5R)-3-(dimethoxy-phosphoryl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-phenoxythiocarbonyloxy-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / H₂NNH₂*H₂O / acetic acid; pyridine / 24 h / Ambient temperature

2: 4-(DMAP) / CH₂Cl₂ / 1 h / Ambient temperature

With dmap; hydrazine hydrate; In pyridine; dichloromethane; acetic acid;
DOI:10.1016/S0040-4020(01)85564-2