tert-butyl 3α-[N-Boc-N,O-(4-methoxybenzylidene)-β-phenylisoserinoyl]-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate

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Chemical Name:tert-butyl 3α-[N-Boc-N,O-(4-methoxybenzylidene)-β-phenylisoserinoyl]-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate
CAS No.:870133-55-4
Molecular Formula:C₅₂H₇₀F₃NO₁₁
Molecular Weight:942.123
Hs Code.:

Synonyms:tert-butyl 3α-[N-Boc-N,O-(4-methoxybenzylidene)-β-phenylisoserinoyl]-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate

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Chemical Property of tert-butyl 3α-[N-Boc-N,O-(4-methoxybenzylidene)-β-phenylisoserinoyl]-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate

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Technology Process of tert-butyl 3α-[N-Boc-N,O-(4-methoxybenzylidene)-β-phenylisoserinoyl]-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate

There total 1 articles about tert-butyl 3α-[N-Boc-N,O-(4-methoxybenzylidene)-β-phenylisoserinoyl]-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: (2S,4R,5S)-2-(4-Methoxy-phenyl)-4-phenyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester

: 130781-88-3
tert-butyl 3α,7α-dihydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate

: 870133-55-4
tert-butyl 3α-[N-Boc-N,O-(4-methoxybenzylidene)-β-phenylisoserinoyl]-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In toluene; at 80 ℃; for 16h;
DOI:10.1002/ejoc.200500203

Reference yield:

: 870133-55-4
tert-butyl 3α-[N-Boc-N,O-(4-methoxybenzylidene)-β-phenylisoserinoyl]-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate

: tert-butyl 7α-benzoyloxy-3α-(N-Boc-β-phenylisoserinoyl)-12α-hydroxy-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / 4-(dimethylamino)pyridine / pyridine / 3 h / 90 °C

2: 77 percent / PTSA / methanol / 3 h / 20 °C

3: 52 percent / NH₄OH / H₂O; methanol; tetrahydrofuran / 1 h

With dmap; ammonium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; methanol; water;
DOI:10.1002/ejoc.200500203

Reference yield:

: 870133-55-4
tert-butyl 3α-[N-Boc-N,O-(4-methoxybenzylidene)-β-phenylisoserinoyl]-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate

: 870133-61-2
tert-butyl 7α-benzoyloxy-3α-(N-Boc-β-phenylisoserinoyl)-12α-trifluoroacetoxy-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / 4-(dimethylamino)pyridine / pyridine / 3 h / 90 °C

2: 77 percent / PTSA / methanol / 3 h / 20 °C

With dmap; toluene-4-sulfonic acid; In pyridine; methanol;
DOI:10.1002/ejoc.200500203