methyl-(4-nitro-phenyl)-carbamic acid 3-hydroxy-3-methyl-hex-5-enyl ester

Base Information

Chemical Name:methyl-(4-nitro-phenyl)-carbamic acid 3-hydroxy-3-methyl-hex-5-enyl ester
CAS No.:246237-00-3
Molecular Formula:C₁₅H₂₀N₂O₅
Molecular Weight:308.334
Hs Code.:

Synonyms:methyl-(4-nitro-phenyl)-carbamic acid 3-hydroxy-3-methyl-hex-5-enyl ester

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Chemical Property of methyl-(4-nitro-phenyl)-carbamic acid 3-hydroxy-3-methyl-hex-5-enyl ester

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Technology Process of methyl-(4-nitro-phenyl)-carbamic acid 3-hydroxy-3-methyl-hex-5-enyl ester

There total 2 articles about methyl-(4-nitro-phenyl)-carbamic acid 3-hydroxy-3-methyl-hex-5-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53696-52-9
N-methyl-N-(4-nitrophenyl)carbamoyl chloride

: 114580-75-5
(R/S)-3-methyl-5-hexene-1,3-diol

: 246237-00-3
methyl-(4-nitro-phenyl)-carbamic acid 3-hydroxy-3-methyl-hex-5-enyl ester

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; toluene; at 20 ℃; for 90h;
DOI:10.1021/ja991507g

Reference yield:

: 100-15-2
N-methyl(p-nitroaniline)

: 246237-00-3
methyl-(4-nitro-phenyl)-carbamic acid 3-hydroxy-3-methyl-hex-5-enyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / toluene; tetrahydrofuran / 0.25 h / 0 °C

2: 285 mg / DMAP; NEt₃ / tetrahydrofuran; toluene / 90 h / 20 °C

With dmap; triethylamine; In tetrahydrofuran; toluene; 1: Acylation / 2: Acylation;
DOI:10.1021/ja991507g

Reference yield:

: 246237-00-3
methyl-(4-nitro-phenyl)-carbamic acid 3-hydroxy-3-methyl-hex-5-enyl ester

: 674-26-0,503-48-0
mevalonolactone

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methylmorpholine N-oxide; OsO₄ / CH₂Cl₂; H₂O; 2-methyl-propan-2-ol / 0.75 h

2: 409.1 mg / Pb(OAc)4 / CH₂Cl₂; H₂O; 2-methyl-propan-2-ol / 0.17 h

3: 77 percent / KMnO₄ / diethyl ether; aq. phosphate buffer; 2-methyl-propan-2-ol / 0.08 h / 20 °C / pH 7.4

4: 17 percent / NaOH / methanol / 20 °C

With lead(IV) acetate; sodium hydroxide; potassium permanganate; osmium(VIII) oxide; 4-methylmorpholine N-oxide; In methanol; phosphate buffer; diethyl ether; dichloromethane; water; tert-butyl alcohol; 1: Dihydroxylation / 2: Oxidation / 3: Oxidation / 4: Cyclization;
DOI:10.1021/ja991507g