N-<1,5-dimethyl-2-phenyl-4-carboxypyrrol-3-yl>methylaminomethylenemalonic acid diethyl ester

Base Information

• Chemical Name: N-<1,5-dimethyl-2-phenyl-4-carboxypyrrol-3-yl>methylaminomethylenemalonic acid diethyl ester
• CAS No.: 100856-24-4
• Molecular Formula: C₂₂H₂₆N₂O₆
• Molecular Weight: 414.458
• Mol file: 100856-24-4.mol

Synonyms:N-<1,5-dimethyl-2-phenyl-4-carboxypyrrol-3-yl>methylaminomethylenemalonic acid diethyl ester

Chemical Property of N-<1,5-dimethyl-2-phenyl-4-carboxypyrrol-3-yl>methylaminomethylenemalonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<1,5-dimethyl-2-phenyl-4-carboxypyrrol-3-yl>methylaminomethylenemalonic acid diethyl ester

There total 1 articles about N-<1,5-dimethyl-2-phenyl-4-carboxypyrrol-3-yl>methylaminomethylenemalonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-<2-phenyl-1,5-dimethyl-4-t-butoxycarbonylpyrrol-3-yl>methylaminomethylenemalonic acid, diethyl ester (100856-23-3) → N-<1,5-dimethyl-2-phenyl-4-carboxypyrrol-3-yl>methylaminomethylenemalonic acid diethyl ester (100856-24-4)

Guidance literature:

With methanesulfonic acid; for 0.166667h; Ambient temperature;

DOI:10.1002/jhet.5570220323

Reference yield: 94.0%

N-<1,5-dimethyl-2-phenyl-4-carboxypyrrol-3-yl>methylaminomethylenemalonic acid diethyl ester (100856-24-4) → 3-carbethoxy-7-phenyl-1,5,6-trimethyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine (100856-28-8)

Guidance literature:

With polyphosphoric ester; at 100 - 110 ℃; for 1.5h;

DOI:10.1002/jhet.5570220323

Reference yield:

N-<1,5-dimethyl-2-phenyl-4-carboxypyrrol-3-yl>methylaminomethylenemalonic acid diethyl ester (100856-24-4) → 7-phenyl-1,5,6-trimethyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine-3-carboxylic acid (100856-36-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / polyphosphoric ester / 1.5 h / 100 - 110 °C

2: 75 percent / sodium hydroxide (1 percent) / methanol; H₂O / heating on a boiling water bath, 1 hr.,

With sodium hydroxide; polyphosphoric ester; In methanol; water;

DOI:10.1002/jhet.5570220323

upstream raw materials:

N-<2-phenyl-1,5-dimethyl-4-t-butoxycarbonylpyrrol-3-yl>methylaminomethylenemalonic acid, diethyl ester

Downstream raw materials:

3-carbethoxy-7-phenyl-1,5,6-trimethyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine

7-phenyl-1,5,6-trimethyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine-3-carboxylic acid