N-(3-{1-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Base Information

Chemical Name:N-(3-{1-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]-4-piperidinyl}phenyl)-2-methylpropanamide
CAS No.:387826-52-0
Molecular Formula:C₂₇H₃₃N₃O₃
Molecular Weight:447.577
Hs Code.:

Synonyms:N-(3-{1-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]-4-piperidinyl}phenyl)-2-methylpropanamide

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Chemical Property of N-(3-{1-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Chemical Property:

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Technology Process of N-(3-{1-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]-4-piperidinyl}phenyl)-2-methylpropanamide

There total 7 articles about N-(3-{1-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]-4-piperidinyl}phenyl)-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 387826-52-0
N-(3-{1-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Guidance literature:

Reference yield:

: 430464-44-1
N-(3-iodophenyl)isobutyramide

: 387826-52-0
N-(3-{1-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / PdCl₂dppf / dimethylformamide / 80 °C

2: H₂ / Pd/C / ethyl acetate; methanol / 20 °C / 10343.2 Torr

3: HCl / dioxane / 1 h / 20 °C

4: Bu₄NI; EtN(i-Pr)2 / dioxane / 99 °C

With hydrogenchloride; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; In 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1021/jm060381c

Reference yield:

: 387827-30-7
4-[3-(isobutyrylamino)phenyl]-3,6-dihydro-1(2H)-pyridine carboxylic acid tert-butyl ester

: 387826-52-0
N-(3-{1-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / ethyl acetate; methanol / 20 °C / 10343.2 Torr

2: HCl / dioxane / 1 h / 20 °C

3: Bu₄NI; EtN(i-Pr)2 / dioxane / 99 °C

With hydrogenchloride; hydrogen; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethyl acetate;
DOI:10.1021/jm060381c