2-((3R,5R,6S)-5-(3-chlorophenyl)-6-( 4-chlorophenyl)-1-( (2S,3S)-2-methoxypentan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

Base Information

Chemical Name:2-((3R,5R,6S)-5-(3-chlorophenyl)-6-( 4-chlorophenyl)-1-( (2S,3S)-2-methoxypentan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid
CAS No.:1352064-71-1
Molecular Formula:C₂₆H₃₁Cl₂NO₄
Molecular Weight:492.442
Hs Code.:

Synonyms:2-((3R,5R,6S)-5-(3-chlorophenyl)-6-( 4-chlorophenyl)-1-( (2S,3S)-2-methoxypentan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

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Chemical Property of 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-( 4-chlorophenyl)-1-( (2S,3S)-2-methoxypentan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

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Technology Process of 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-( 4-chlorophenyl)-1-( (2S,3S)-2-methoxypentan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

There total 2 articles about 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-( 4-chlorophenyl)-1-( (2S,3S)-2-methoxypentan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1352076-47-1
methyl 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-( 4-chlorophenyl)-1-((2S,3S)-2-methoxypentan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetate

: 1352064-71-1
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-( 4-chlorophenyl)-1-( (2S,3S)-2-methoxypentan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 4h;
DOI:10.1021/ml500142b

Reference yield:

: 1352064-70-0
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((2S,3S)-2-hydroxypentan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

: 1352064-71-1
2-((3R,5R,6S)-5-(3-chlorophenyl)-6-( 4-chlorophenyl)-1-( (2S,3S)-2-methoxypentan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

1.2: 3 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 20 °C

2.2: 0.5 h

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 4 h / 20 °C

With water; sodium hydride; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ml500142b