6-(4-fluorophenyl)-3,4-dimethoxypyridazine

Base Information

• Chemical Name: 6-(4-fluorophenyl)-3,4-dimethoxypyridazine
• CAS No.: 1581767-57-8
• Molecular Formula: C₁₂H₁₁FN₂O₂
• Molecular Weight: 234.23
• Mol file: 1581767-57-8.mol

Synonyms:6-(4-fluorophenyl)-3,4-dimethoxypyridazine

Chemical Property of 6-(4-fluorophenyl)-3,4-dimethoxypyridazine

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-fluorophenyl)-3,4-dimethoxypyridazine

There total 1 articles about 6-(4-fluorophenyl)-3,4-dimethoxypyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-fluoroboronic acid (1765-93-1) + 6-chloro-3,4-dimethoxypyridazine (2096-21-1) → 6-(4-fluorophenyl)-3,4-dimethoxypyridazine (1581767-57-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; for 3h; Reflux; Inert atmosphere;

Reference yield: 36.0%

6-(4-fluorophenyl)-3,4-dimethoxypyridazine (1581767-57-8) → 6-(4-fluorophenyl)-4-methoxypyridazin-3(2H)-one (1581767-58-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; for 11h; Reflux;

Reference yield:

6-(4-fluorophenyl)-3,4-dimethoxypyridazine (1581767-57-8) → 6-(4-fluorophenyl)-4-hydroxypyridazin-3(2H)-one (1581767-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; water / 11 h / Reflux; Inert atmosphere

2: boron tribromide / dichloromethane / 36 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; boron tribromide; In 1,4-dioxane; dichloromethane; water;

DOI:10.1021/jm500958x

upstream raw materials:

4-fluoroboronic acid

6-chloro-3,4-dimethoxypyridazine

Downstream raw materials:

6-(4-fluorophenyl)-4-hydroxypyridazin-3(2H)-one

6-(4-fluorophenyl)-4-methoxypyridazin-3(2H)-one

Refernces

• 1、 Sagong, Hye Yeon,Bauman, Joseph D.,Patel, Disha,Das, Kalyan,Arnold, Eddy,Lavoie, Edmond J.. "Phenyl substituted 4-hydroxypyridazin-3(2 H)-ones and 5-hydroxypyrimidin-4(3 H)-ones: Inhibitors of influenza a endonuclease". . p. 8086 - 8098. Retrieved 2014/12/10.