6-butyl-2-methyl-7-(2-phenoxyethoxy)-3-(4-(trifluoromethyl)phenyl)quinolin-4(1H)-one

Base Information

Chemical Name:6-butyl-2-methyl-7-(2-phenoxyethoxy)-3-(4-(trifluoromethyl)phenyl)quinolin-4(1H)-one
CAS No.:1349820-77-4
Molecular Formula:C₂₉H₂₈F₃NO₃
Molecular Weight:495.541
Hs Code.:

Synonyms:6-butyl-2-methyl-7-(2-phenoxyethoxy)-3-(4-(trifluoromethyl)phenyl)quinolin-4(1H)-one

Suppliers and Price of 6-butyl-2-methyl-7-(2-phenoxyethoxy)-3-(4-(trifluoromethyl)phenyl)quinolin-4(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-butyl-2-methyl-7-(2-phenoxyethoxy)-3-(4-(trifluoromethyl)phenyl)quinolin-4(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-butyl-2-methyl-7-(2-phenoxyethoxy)-3-(4-(trifluoromethyl)phenyl)quinolin-4(1H)-one

There total 9 articles about 6-butyl-2-methyl-7-(2-phenoxyethoxy)-3-(4-(trifluoromethyl)phenyl)quinolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1349820-67-2
6-butyl-3-iodo-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1349820-77-4
6-butyl-2-methyl-7-(2-phenoxyethoxy)-3-(4-(trifluoromethyl)phenyl)quinolin-4(1H)-one

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm200718m

Reference yield:

: 1349820-44-5
6-butyl-2-methyl-7-(2-phenoxyethoxy)quinolin-4(1H)-one

: 1349820-77-4
6-butyl-2-methyl-7-(2-phenoxyethoxy)-3-(4-(trifluoromethyl)phenyl)quinolin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: iodine; potassium iodide; sodium hydroxide / methanol / 2 h / 20 °C

2: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iodine; potassium iodide; sodium hydroxide; In methanol; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1021/jm200718m

Reference yield:

: 28583-62-2
N-(4-butyryl-3-hydroxyphenyl)acetamide

: 1349820-77-4
6-butyl-2-methyl-7-(2-phenoxyethoxy)-3-(4-(trifluoromethyl)phenyl)quinolin-4(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate / 0.5 h / 0 °C

2.1: palladium 10% on activated carbon; hydrogen / acetic acid / 3102.97 Torr

3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 75 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: potassium hydroxide / ethanol; water / 0 °C / Reflux

5.1: acetic acid / benzene / Reflux

5.2: 0.25 h / Reflux

6.1: iodine; potassium iodide; sodium hydroxide / methanol / 2 h / 20 °C

7.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium tetrahydroborate; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; iodine; sodium hydride; acetic acid; potassium iodide; potassium hydroxide; sodium hydroxide; In methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide; benzene; 5.1: Conrad-Limpach synthesis / 7.1: Suzuki coupling;
DOI:10.1021/jm200718m