13-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-tridecanoic acid tert-butyl ester

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Chemical Name:13-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-tridecanoic acid tert-butyl ester
CAS No.:234081-80-2
Molecular Formula:C₆₅H₁₁₆N₄O₈
Molecular Weight:1081.66
Hs Code.:

Synonyms:13-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-tridecanoic acid tert-butyl ester

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Chemical Property of 13-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-tridecanoic acid tert-butyl ester

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Technology Process of 13-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-tridecanoic acid tert-butyl ester

There total 6 articles about 13-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-tridecanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 234082-00-9
1,12-dodecanedicarboxylic acid mono-tert-butyl ester

: 234081-53-9
(S)-2-Amino-N-((S)-1,2-bis-hexadecylcarbamoyl-ethyl)-succinamic acid benzyl ester

: 234081-80-2
13-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-tridecanoic acid tert-butyl ester

Guidance literature:: With dmap; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-hydroxybenzotriazol-hydrate; In chloroform; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0009-3084(02)00053-1

Reference yield:

: 143-27-1
hexadecylamine

: 234081-80-2
13-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-tridecanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / 1-hydroxybenzotriazole hydrate; 2-(1H-benzotriazol-1-yl)-1,1,3,3,-tetramethyluronium*BF₄^(1-); 4-dimethylaminopyridine / CHCl₃; dimethylformamide / 3 h / 20 °C

2: 78 percent / trifluoroacetic acid / CHCl₃ / 2 h / 20 °C

3: 46 percent / 1-hydroxybenzotriazole hydrate; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; 4-dimethylaminopyridine / CH₂Cl₂; dimethylformamide / 5 h / 20 °C

4: 81 percent / trifluoroacetic acid / CHCl₃ / 1 h / 20 °C

5: 42 percent / 1-hydroxybenzotriazole hydrate; 2-(1H-benzotriazol-1-yl)-1,1,3,3,-tetramethyluronium*BF₄^(1-); 4-dimethylaminopyridine / CHCl₃; dimethylformamide / 20 °C

With dmap; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0009-3084(02)00053-1

Reference yield:

: 821-38-5
1,14-tetradecanedioic acid

: 234081-80-2
13-[(S)-1-Benzyloxycarbonyl-2-((S)-1,2-bis-hexadecylcarbamoyl-ethylcarbamoyl)-ethylcarbamoyl]-tridecanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 30 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide*HCl; 4-dimethylaminopyridine / CH₂Cl₂ / 20 °C

2: 42 percent / 1-hydroxybenzotriazole hydrate; 2-(1H-benzotriazol-1-yl)-1,1,3,3,-tetramethyluronium*BF₄^(1-); 4-dimethylaminopyridine / CHCl₃; dimethylformamide / 20 °C

With dmap; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0009-3084(02)00053-1